بررسی نقش التهاب و استرس اکسیداتیو در اختلال کبدی متابولیسم گلوکز القا شده با مالاتیون

Title

Oxidative stress and inflammation in malathion disrupted hepatic glucose metabolism

English Abstract

Purpose: A lot of studies show that organophosphate pesticides exert several effects on glucose homeostasis. The present study investigates the influence of subchronic exposure to malathion on hepatic gluconeogenesis in relation to acetyl cholinesterase inhibition, oxidative stress and inflammatory response in the rat. Methods:Malathion was administered by gavage at doses of 25, 50 and 100 mg/kg for 32 days. Results & Conclusion: Fasting hyperglycemia was seen in line with increased activity of hepatic phosphoenolpyruvate carboxykinase, glucose 6-phosphatase, and tumor necrosis factor alpha. In addition to the impaired glucose tolerance and inhibition of acetyl cholinesterase activity in a dose-dependent manner, there were significant increases in hepatic lipid peroxidation, carbonyl groups and 8-deoxyguanosine as the biomarkers of reactive oxygen species mediated damage to lipid, protein and DNA, respectively. The results suggest the possibility of malathion-induced insulin resistance in the liver through oxidative and inflammatory signaling pathways.

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