title

پروپولیس القاء می کند سمیت سلولی بر روی سلول های سرطانی ایزوله شده از مدل موش صحرایی مبتلاء به هپاتوسلولار کارسینوما، درگیری تارگت میتوکندریایی وابسته به (ROS)

صیدی, عنایت اله and میرحسینی, سحر and سلیمی, احمد and پوراحمد, جلال (1395) پروپولیس القاء می کند سمیت سلولی بر روی سلول های سرطانی ایزوله شده از مدل موش صحرایی مبتلاء به هپاتوسلولار کارسینوما، درگیری تارگت میتوکندریایی وابسته به (ROS). PharmaNutrition ــ 4 (4). pp. 143-150. شاپا 2213-4344

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Title

Propolis induce cytotoxicity on cancerous hepatocytes isolated from rat model of hepatocellular carcinoma: Involvement of ROS-mediated mitochondrial targeting

English Abstract

Hepatocellular carcinoma (HCC) is the third cause of mortality due to cancer throughout the world. Propolis is a beehive product with a specific chemical composition, widely used in traditional medicine because of its several pharmacological activities. Propolis has attracted much attention in recent years as a useful substance having application in medicine and cosmetics. Many studies have shown that propolis contain anti-cancer compounds. The present research was designed to evaluate the selective cytotoxicity of ethanolic extracts of propolis (EEP) sample purchased from Kurdistan province, Iran on hepatocytes and mitochondria obtained from the liver of HCC induced rats. HCC was induced by diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) method. Our results showed that EEP (75, 150 and 300 μg/ml) selectively induced mitochondrial membrane potential (MMP)decrease, mitochondrial swelling and cytochrome c release by increasing reactive oxygen species (ROS) generation and also caspase-3 activation in hepatocytes and mitochondria isolated from liver of HCC induced but not untreated normal rats. Our results provided evidence for the hypothesis that Iranian propolis could show a promising selective toxicity on HCC rat hepatocytes through directly mitochondrial targeting and apoptosis induction.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :عنایت اله صیدی
نویسنده :احمد سلیمی
نویسنده مسئول :جلال پوراحمد
Additional Information:Indexed in: Scopus, Chemical Abstracrs,Embase, Google Scholar
کلیدواژه ها (انگلیسی):Propolis; Apoptosis; Hepatocytes; Mitochondria; Hepatocellular carcinoma
Subjects:QV pharmacology > QV 600 Toxicology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:8171
Deposited By: دکتر احمد سلیمی
Deposited On:13 Sep 1395 12:30
Last Modified:03 Oct 1396 11:55

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