تجویزهای تکراری جیوه پیشرفت بیماری مالتپل اسکلروزیس (MS) را از طریق آسیب به میتوکندری ها تسریع می کند.

کهریزی, فرزاد and سلیمی, احمد and نوربخش, فرشید and فیضی, مهرداد and مهری, فرشته and ناصر زاده, پروانه and نادری, نیما and پوراحمد, جلال (1395) تجویزهای تکراری جیوه پیشرفت بیماری مالتپل اسکلروزیس (MS) را از طریق آسیب به میتوکندری ها تسریع می کند. Iranian Journal of Pharmaceutical Research ــ 15 (4). pp. 835-841. شاپا 1735-0328


Official URL: http://ijpr.sbmu.ac.ir


Repeated Administration of Mercury Intensifies Brain Damage in Multiple Sclerosis through Mitochondrial Dysfunction

English Abstract

In this study we investigated the additive effect of mercury on the brain mitochondrial dysfunction in experimental autoimmune encephalomyelitis (EAE) model. Experimental animals (female C57BL/6 mice) are divided into four groups (n = 8); control, Hg, EAE, EAE with Hg. EAE model of MS induced by injecting myelin oligodendrocyte glycoprotein (MOG). Neurobehavioral alterations are recorded and then mice were sacrificed at day 28 and brain mitochondria were isolated and mitochondrial toxicity parameters including mitochondrial swelling, reactive oxygen species (ROS) formation, collapse of mitochondrial membrane potential (MMP) and cytochrome c release were measured. Our results showed that repeated treatment of mercury following induction of EAE in mice significantly increased the neurobehavioral scores, as well as mitochondrial toxicity through ROS formation, mitochondrial swelling, collapse of MMP and cytochrome c release. Our findings proved that repeated exposure with mercury accelerates progression of MS through mitochondrial damage related to oxidative stress and finally apoptosis.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :فرزاد کهریزی
نویسنده :احمد سلیمی
نویسنده :فرشید نوربخش
نویسنده :مهرداد فیضی
نویسنده :فرشته مهری
نویسنده :پروانه ناصر زاده
نویسنده مسئول :نیما نادری
نویسنده مسئول :جلال پوراحمد
Additional Information:IF: 1.507 Indexed in: SI, Scopus, PubMed/PMC, Embase
کلیدواژه ها (انگلیسی):Mercury; EAE model; Brain mitochondria; Oxidative stress; Apoptosis
Subjects:QV pharmacology > QV 25 Pharmaceutical Biomaterials
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:8172
Deposited By: Dr Ahmad Salimi
Deposited On:10 Nov 1395 07:56
Last Modified:25 Jan 1401 08:11

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