اثر محافظتی تروگزروتین بر تقویت بلند مدت نورون های شکنج دندانه دار در مدل آلزایمری بتا آمیلوئید

امانی, محمد and محدث, گیسو and ببری, شیرین (1391) اثر محافظتی تروگزروتین بر تقویت بلند مدت نورون های شکنج دندانه دار در مدل آلزایمری بتا آمیلوئید. در: 2nd Tehran IBRO School of Neuroscience, May 12-23, 2012, Tehran - Iran.



Effect of Troxerutin on long-term potentiation (LTP) of dentate gyrus neurons in a β-amyloid model of Alzheimer’s disease

English Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that impairs ability of learning and memory. β-Amyloid (Aβ) is a primary factor leading to this neurodegenerative disorder. The present study investigated the protective effect of Troxerutin, a derivative of natural bioflavonoid, on long-term potentiation (LTP) in dentate gyrus neurons of hippocampus in a β-amyloid model of Alzheimer’s disease. Male Wistar rats weighing were divided into three groups, sham-operated, Aβ1-42 injected and Aβ1-42 plus Troxerutin-treated animals. Troxerutin (300 mg/kg) was administered by gavage for 14 days after intracerebroventricular injection of Aβ1-42. Troxerutin treatment enhanced LTP in dentate gyrus neurons blocked by Aβ1-42. These findings suggest that Troxerutin could have a beneficial effect on learning and memory impairment induced by Aβ (1– 42) in Alzheimer’s disease.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده مسئول :محمد امانی
نویسنده :گیسو محدث
نویسنده :شیرین ببری
Subjects:QT physiology
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:8187
Deposited By: Dr Mohammad Amani
Deposited On:17 Sep 1395 05:47
Last Modified:21 Sep 1395 05:08

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