اثر محیط بر ویژگی های طیفی و توزیع بار برخی از داروها مشتقات فولات (2017)

خادم صدیق, مهسا and ذاکرحمیدی, محمدصادق and سید احمدیان, سیدمسعود and جوهری اهر, محمد and زارع حقیقی, ل (1395) اثر محیط بر ویژگی های طیفی و توزیع بار برخی از داروها مشتقات فولات (2017). Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy ــ 171 . pp. 10-17. شاپا 1386-1425

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Official URL: http://www.sciencedirect.com/science/article/pii/S...


Environment effect on spectral and charge distribution characteristics of some drugs of folate derivatives

English Abstract

Molecular surrounding media as an important factor can effect on the operation of wide variety of drugs. For more study in this paper, spectral properties of Methotrexate and Folinic acid have been studied in various solvents. Our results show that the photo-physical of solute molecules depend strongly on solute-solvent interactions and active groups in their chemical structures. In order to investigate the contribution of specific and nonspecific interactions on the various properties of drug molecules, the linear solvation energy relationships concept is used. Moreover, charge distribution characteristics of used samples with various resonance structures in solvent environments were calculated by means of solvatochromic method. The high value of dipole moments in excited state show that local intramolecular charge transfer can occur by excitation. These results about molecular interactions can be extended to biological systems and can indicate completely the behaviors of Methotrexate and Folinic acid in polar solvents such as water in body system.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :مهسا خادم صدیق
نویسنده :محمدصادق ذاکرحمیدی
نویسنده :سیدمسعود سید احمدیان
نویسنده :محمد جوهری اهر
Additional Information:Impact Factor (2016) 2.536 Indexed in: ISI, Pubmed/Medline/Inde Medicus, Scopus, Chemical Abstracts, Analytical Abstracts, Cambridge Scientific Abstracts,Current Contents/Physics, Chemical, & Earth Sciences, INSPEC نوع مقاله: Original Research
کلیدواژه ها (انگلیسی):Methotrexate, Folinic acid, Solvent polarity, Linear salvation energy relationship, Local intramolecular charge transfer
Subjects:QV pharmacology > QV 744 Medicinal Chemistry
QV pharmacology
Divisions:School of Pharmacy > Department of Medicinal Chemistry
ID Code:8213
Deposited By: Dr Mohammad Johari-Ahar
Deposited On:16 Sep 1395 06:50
Last Modified:19 Sep 1396 12:30

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