title

اثرات محیط و حلال بر رفتارهای نوری فیزیکی اسید فولیک و اسید فولینیک

خادم صدیق, مهسا and ذاکرحمیدی, محمدصادق and سید احمدیان, سیدمسعود and جوهری اهر, محمد and زارع حقیقی, ل (1395) اثرات محیط و حلال بر رفتارهای نوری فیزیکی اسید فولیک و اسید فولینیک. Journal of Molecular Structure ــ 1125 . pp. 177-185. شاپا 0022-2860

[img] Text
محدود به Repository staff only

1MB

Official URL: http://www.sciencedirect.com/science/journal/00222...


Title

Environment and solute-solvent interaction effects on photo-physical behaviors of Folic acid and Folinic acid drugs

English Abstract

In this paper, spectral properties of Folic acid and Folinic acid as widely used drugs in the treatment of some diseases have been studied in various environments with different polarity. Our results show that the absorption, emission and stokes shifts of solute molecules depend strongly on molecular surrounding characteristics, solute-solvent interactions and, different active groups in their chemical structures. In order to investigate the contribution of specific and nonspecific interactions on various properties of drug samples, the linear solvation energy relationships concept is used. Moreover, the calculated dipole moments by means of solvatochromic method show that the high values of dipole moments in excited state are due to local intramolecular charge transfer. Furthermore, the obtained results about molecular interactions can be extended to biological systems and can indicate completely the behaviors of Folic acid and Folinic acid in polar solvents such as water in body system.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :مهسا خادم صدیق
نویسنده :محمدصادق ذاکرحمیدی
نویسنده :سیدمسعود سید احمدیان
نویسنده :محمد جوهری اهر
نویسنده :ل زارع حقیقی
Additional Information:Impact Factor(2015) 1.78 Indexed in: ISI, SCopus, Chemical Abstracts, Current Contents/Physics, Chemical, & Earth Sciences, Mass Spectrometry Bulletin, PASCAL/CNRS
کلیدواژه ها (انگلیسی):Folic acid, Folinic acid, Local intramolecular charge transfer, Linear salvation energy relationship, Dipole moment
Subjects:QV pharmacology > QV 744 Medicinal Chemistry
QV pharmacology
Divisions:School of Pharmacy > Department of Medicinal Chemistry
ID Code:8214
Deposited By: MR Mohammad Johari-Ahar
Deposited On:16 Sep 1395 07:59
Last Modified:24 Mar 1397 13:07

Repository Staff Only: item control page

Document Downloads

More statistics for this item...