هایپرسیستینمی،ویتامین ب 12 و فولیک اسید پایین:ایا ریسک فاکتورهای ترومبوز عروق مغزی در شمال غرب ایران هستند؟

طاهراقدم, علی اکبر and دلیر اکبری, نوریه and خلیلی, محمد and سلطانی, مجید and صادقیه اهری, سعید (1394) هایپرسیستینمی،ویتامین ب 12 و فولیک اسید پایین:ایا ریسک فاکتورهای ترومبوز عروق مغزی در شمال غرب ایران هستند؟. journal of research in medical sciences ــ 21 (1). شاپا 1735-1995


Official URL: http://jrms.mui.ac.ir


Hyperhomocysteinemia, low vitamin B12, an low folic acid:Are risk factors of cerebral vascular thrombosis in northwest Iran

English Abstract

Background: Cerebral vascular thrombosis (CVT) is the thrombosis of intracranial and sinuses. The aim of this is to estimate of risk of low folic acid, low vitamin B12, and hyperhomocysteinemia (hyper-Hcys) for CVT. Materials and Methods: A total of 24 patients with CVT and 36 healthy controls participated in a cross-sectional case-control study. The deficient levels of folic acid and vitamin B12 defined as <10th percentile of folic acid and vitamin B12 level and hyper-Hcys was defined as >90th percentile of homocysteine of control group. Results: Patients had higher levels of total homocysteine (tHcys) than controls (14.7 ± 6.5 vs. 6.4 ± 2.7 μmol/L, P = 0.001). Also, vitamin B12 level in case group was lower compared to control subjects (185.4 ± 58 vs. 299 ± 75 ng/mL, P = 0.001). Hyper-Hcys and low vitamin B12 were significantly more prevalent in CVT patients than controls. Although, significant independent association with risk of CVT was found for hyper-Hcys [adjusted odds ratio (OR) 14.3, 95% confidence interval (CI): 2.6-77.1, P = 0.002] and low vitamin B12 (adjusted OR 24.6, 95% CI: 2.3-262.9, P = 0.008). Association between low folic acid and risk of CVT was not significant. A significant negative correlation was found between the levels of tHcys and vitamin B12 (r = −0.32, P = 0.01). Conclusion: Hyper-Hcys and low vitamin B12 were related with the high risk for CVT.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :علی اکبر طاهراقدم
نویسنده مسئول :مجید سلطانی
نویسنده :سعید صادقیه اهری
Additional Information:Impact Factor (2015) 0.812 Indexed in: ISI, Pubmed, Scopus, Chemical Abstracts
کلیدواژه ها (انگلیسی):Cerebral vascular thrombosis (CVT), deficiency, folic acid, hyperhomocysteinemia (hyper-Hcys), vitamin B12
Subjects:WL Nervous system
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
ID Code:8416
Deposited By: Dr Saeid Sadeghiyeh Ahari
Deposited On:18 Oct 1395 09:49
Last Modified:10 Nov 1397 09:25

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