صالح پور, معصومه ، طیبی میبد ی, ناصر ، تیمورپور, رقیه ، قرآنی اعظم, عادل ، سپاهی, سمانه ، رستمی, سینا ، مشکات, زهرا (1394) فراوانی پاپیلوماویروس انسانی ژنوتیپ های 6و11و16و18وو31از نمونه های بافتی کارسینومای مهاجم پستان ،شمال شرق ایران. Iranian Journal of Pathology ــ 10 (3). 192 - 198. شاپا 1735-5303
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آدرس اینترنتی رسمی : http://ijp.iranpath.org
عنوان انگليسی
Frequency of Human Papillomavirus Genotypes 6, 11, 16, 18 And 31 in Paraffin-Embedded Tissue Samples of Invasive Breast Carcinoma, North- East of Iran
خلاصه انگلیسی
Background &Objective: Breast cancer is the most common female malignancy. Detection of DNA of human papillomaviruses (HPVs) in breast carcinomas suggests that the virus may play a role in the pathogenesis of this disease. The aim of this study was to evaluate the frequency of HPVs genotypes 6, 11, 16, 18 and 31 in paraffin-embedded tissue samples of invasive breast carcinomas. Methods: Three hundred and twenty six paraffin-embedded tissue samples of breast cancer were studied. PCR was performed using specific primers for HPV genotypes. Results: Of total 206 (63.2%) samples positive for Beta-globin gene, 54 (26.2%) were HPV-positive and 152 (73.8%) were negative for HPV. Distribution of HPV genotypes were as follows: 19(25.7%) were positive for genotype 11, 5 (6.8%) were positive for genotype 6; and 2 cases (2.7%) were positive for both genotypes 6 and 11. Samples were also screened for HPV genotypes 16, 18 and 31 but none was positive. Conclusion: The current study confirmed the association of HPV and breast cancer. However, all samples were negative for high-risk HPV types 16, 18 and 31.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | معصومه صالح پور |
نویسنده مسئول : | زهرا مشکات |
ضریب تاثیر و نمایه مجلات: | Indexed in: Pubmed/PMC, Scopus, ISC, DOAJ, SID, EBSCO, magiran, IranMedex, Google Scholar, CINAHL, |
کلیدواژه ها (انگلیسی): | Human Papillomavirus (HPV); Breast Cancer; Polymerase Chain Reaction (PCR) |
موضوعات : | QW میکروب شناسی و ایمنی شناسی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش میکروبیولوژی |
کد شناسایی : | 8420 |
ارائه شده توسط : | دکتر رقیه تیمورپور |
ارائه شده در تاریخ : | 13 بهمن 1395 08:00 |
آخرین تغییر : | 06 مرداد 1399 09:38 |
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