فراوانی پاپیلوماویروس انسانی ژنوتیپ های 6و11و16و18وو31از نمونه های بافتی کارسینومای مهاجم پستان ،شمال شرق ایران

صالح پور, معصومه and طیبی میبد ی, ناصر and تیمورپور, رقیه and قرآنی اعظم, عادل and سپاهی, سمانه and رستمی, سینا and مشکات, زهرا (1394) فراوانی پاپیلوماویروس انسانی ژنوتیپ های 6و11و16و18وو31از نمونه های بافتی کارسینومای مهاجم پستان ،شمال شرق ایران. Iranian Journal of Pathology ــ 10 (3). 192 - 198. شاپا 1735-5303


Official URL: http://ijp.iranpath.org


Frequency of Human Papillomavirus Genotypes 6, 11, 16, 18 And 31 in Paraffin-Embedded Tissue Samples of Invasive Breast Carcinoma, North- East of Iran

English Abstract

Background &Objective: Breast cancer is the most common female malignancy. Detection of DNA of human papillomaviruses (HPVs) in breast carcinomas suggests that the virus may play a role in the pathogenesis of this disease. The aim of this study was to evaluate the frequency of HPVs genotypes 6, 11, 16, 18 and 31 in paraffin-embedded tissue samples of invasive breast carcinomas. Methods: Three hundred and twenty six paraffin-embedded tissue samples of breast cancer were studied. PCR was performed using specific primers for HPV genotypes. Results: Of total 206 (63.2%) samples positive for Beta-globin gene, 54 (26.2%) were HPV-positive and 152 (73.8%) were negative for HPV. Distribution of HPV genotypes were as follows: 19(25.7%) were positive for genotype 11, 5 (6.8%) were positive for genotype 6; and 2 cases (2.7%) were positive for both genotypes 6 and 11. Samples were also screened for HPV genotypes 16, 18 and 31 but none was positive. Conclusion: The current study confirmed the association of HPV and breast cancer. However, all samples were negative for high-risk HPV types 16, 18 and 31.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :معصومه صالح پور
نویسنده مسئول :زهرا مشکات
Additional Information:Indexed in: Pubmed/PMC, Scopus, ISC, DOAJ, SID, EBSCO, magiran, IranMedex, Google Scholar, CINAHL,
کلیدواژه ها (انگلیسی):Human Papillomavirus (HPV); Breast Cancer; Polymerase Chain Reaction (PCR)
Subjects:QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Microbiology
ID Code:8420
Deposited By: Dr Roghayeh Teimourpour
Deposited On:13 Nov 1395 08:00
Last Modified:06 May 1399 09:38

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