حق نژاد آذر, عادل ، عریان, شهربانو ، بهلولی, شهاب ، پناهپور, حمداله (1395) آلفاتوکوفرول ادم مغزی را کاهش داده و از سد خونی - مغزی پس از وقوع ایسکمی موضعی مغز محافظت می کند(2017). Medical Principles and Practice ــ 26 (1). ص.ص.17-22. شاپا 1011-7571
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آدرس اینترنتی رسمی : https://www.karger.com/Journal/Home/224259
عنوان انگليسی
Alpha-Tocopherol Reduces Brain Edema and Protects Blood-Brain Barrier Integrity following Focal Cerebral Ischemia in Rats
خلاصه انگلیسی
Objective: This study was conducted to examine the neuroprotective effects of α-tocopherol against edema formation and disruption of the blood-brain barrier (BBB) following transient focal cerebral ischemia in rats. Materials and Methods: Ninety-six male Sprague-Dawley rats were divided into 3 major groups (n = 32 in each), namely the sham, and control and α-tocopherol-treated (30 mg/kg) ischemic groups. Transient focal cerebral ischemia (90 min) was induced by occlusion of the left middle cerebral artery. At the end of the 24-hour reperfusion period, the animals were randomly selected and used for 4 investigations (n = 8) in each of the 3 main groups: (a) assessment of neurological score and measurement of infarct size, (b) detection of brain edema formation by the wet/dry method, (c) evaluation of BBB permeability using the Evans blue (EB) extravasation technique, and (d) assessment of the malondialdehyde (MDA) and reduced glutathione (GSH) concentrations using high-performance liquid chromatography methods. Results: Induction of cerebral ischemia in the control group produced extensive brain edema (brain water content 83.8 ± 0.11%) and EB leakage into brain parenchyma (14.58 ± 1.29 µg/g) in conjunction with reduced GSH and elevated MDA levels (5.86 ± 0.31 mmol/mg and 63.57 ± 5.42 nmol/mg, respectively). Treatment with α-tocopherol significantly lowered brain edema formation and reduced EB leakage compared with the control group (p < 0.001, 80.1 ± 0.32% and 6.66 ± 0.87 µg/g, respectively). Meanwhile, treatment with α-tocopherol retained tissue GSH levels and led to a lower MDA level (p < 0.01, 10.17 ± 0.83 mmol/mg, and p < 0.001, 26.84 ± 4.79 nmol/mg, respectively). Conclusion: Treatment with α-tocopherol reduced ischemic edema formation and produced protective effects on BBB function following ischemic stroke occurrence. This effect could be through increasing antioxidant activity
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | عادل حق نژاد آذر |
نویسنده : | شهاب بهلولی |
نویسنده مسئول : | حمداله پناهپور |
ضریب تاثیر و نمایه مجلات: | Impact Factor(2016) 1.469 Indexed in: ISI, Pubmed, Medline/Inde Medicus, Scopus, Google Scholar, Embase, CINAHL Complete, WorldCat |
کلیدواژه ها (انگلیسی): | α-Tocopherol, Cerebral ischemia, Brain edema, Malondialdehyde, Glutathione |
موضوعات : | QT فیزیولوژی QV فارماکولوژی WL سیستم عصبی WT بیماریهای مزمن و بیماریهای سالمندان |
بخش های دانشگاهی : | دانشکده داروسازی > بخش داروسازی بالینی |
کد شناسایی : | 8452 |
ارائه شده توسط : | دکتر حمداله پناهپور |
ارائه شده در تاریخ : | 05 بهمن 1395 11:32 |
آخرین تغییر : | 13 آذر 1396 07:06 |
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