title

اثرات حفاظت پرتوی IMOD و سایمتیدین بر روی آسیبهای سلولی ناشی از اشعه

رهگشائی, سیروس and محمدی, محسن and رفاهی, سهیلا and اولاد غفاری, مریم and آقامیری, سید محمدرضا (1396) اثرات حفاظت پرتوی IMOD و سایمتیدین بر روی آسیبهای سلولی ناشی از اشعه. Journal of Biomedical Physics and Engineering ــ 8 (1). pp. 133-140. شاپا 2251-7200

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Title

Protective Effects of IMOD and Cimetidine against Radiation-induced Cellular Damage

English Abstract

Radiation damage is to a large extent caused by overproduction of reactive oxygen species (ROS). Radioprotectors are agents or substances that reduce the effects of radiation in healthy normal tissues while maintaining the sensitivity to radiation damage in tumor cells. Radioprotectors are agents or substances that reduce the effects of radiation in healthy normal tissues while maintaining the sensitivity to radiation damage in tumor cells Cimetidine was found more effective when used in vivo; this effect might be due to the augmentation of the presence of Sulphur atom in the compound which is ‎important for their scavenging activity. Recently, a new herbal-based medicine with immunomodulatory capacities, Setarud (IMOD), was introduced as an additional therapy in various inflammatory diseases and HIV infection. IMOD is a mixture of herbal extracts enriched with selenium. Selenium confers protection by inducing or activating cellular free-radical scavenging systems and by enhancing peroxide breakdown. This article suggests that nontoxic amount of IMOD and cimetidine have radioprotective properties and could reduce cytotoxic effects of radiation.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سیروس رهگشائی
نویسنده مسئول :محسن محمدی
نویسنده :سهیلا رفاهی
نویسنده :مریم اولاد غفاری
نویسنده :سید محمدرضا آقامیری
Additional Information:Indexed in: Pubmed/PMC, Scopus, EMBASE, EBSCO, DOAJ, Index Copernicus, ISC, SID, Google scholar, Open J-Gate, Geneva Free Medical Journals,EMRmedex, Barakatkns, Magiran, HINARI, Electronic Journals Library
کلیدواژه ها (انگلیسی):Radioprotection, Cimetidine, IMOD, Immunomodulator, Free Radical
Subjects:QZ Pathology
WN Radiology . Diagnostic Imaging
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Medical Physics
ID Code:8469
Deposited By: MS Soheila Refahi
Deposited On:02 Feb 1397 16:34
Last Modified:02 Feb 1397 16:34

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