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تاثیر دسفرال وریدی همراه با ترانسفیوزن خون در کاهش سطح سرمی فریتین در بیماران با تالاسمی ماژور(2017)

فتحی, افشین ، امانی, فیروز ، عرقچین, سمیرا ، فرزانه, اسماعیل (1395) تاثیر دسفرال وریدی همراه با ترانسفیوزن خون در کاهش سطح سرمی فریتین در بیماران با تالاسمی ماژور(2017). International Journal of Basic & Clinical Pharmacology ــ 6 (2). ص.ص.399-403. شاپا 2003-2319

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عنوان انگليسی

Effect of intravenous Deferoxamine concomitant use with blood transfusion on serum ferritin in thalassemia major patients

خلاصه انگلیسی

Background: Subcutaneous Deferoxamineis often not tolerated by patients and its rejection leads to iron overload with its complications. So, other methods with better toleration and reduction of Deferoxamine consumption are necessary. The present study aimed to evaluate the effect of intravenous Deferoxamine infusion during blood transfusion on serum ferritin (SF) in thalassemia major patients. Methods: In a retrospective cross-sectional study, thirty four patients with β-thalassemia major treated with monthly blood transfusion at Bu-Ali hospital in Ardabil city from April 2013 to April 2014, were selected and followed for six months. The mean SF rate and the needed subcutaneous Deferoxamine rates before intervention were considered as baseline. All patients received intravenous Deferoxamine concomitant with their routine monthly blood transfusion for six months. After six months mean values for ferritin, subcutaneous Deferoxamine were compared with baseline values. Collected data were analyzed using t-test and paired t-test by SPSS, version 18.P<0.05 was considered as significant. Results: Compared with baseline, the subcutaneous Deferoxamine rate and ferritin level have been decreased significantly after intervention. Conclusions: Intravenous Deferoxamine concomitant use with routine monthly blood transfusion in thalassemia major patients can lead to decreasing of ferritin level. With this method, patient care could be improved, health care costs and complications of treatment effectively reduced.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :افشین فتحی
نویسنده :فیروز امانی
نویسنده مسئول :اسماعیل فرزانه
ضریب تاثیر و نمایه مجلات:Indexed in: Index Copernicus
کلیدواژه ها (انگلیسی):Beta-thalassemia, Blood transfusion, Deferoxamine
موضوعات :WT بیماریهای مزمن و بیماریهای سالمندان
بخش های دانشگاهی :دانشكده پزشكي > گروه اطفال ، پزشکی اجتماعی
دانشكده پزشكي > گروه داخلی ، قلب ، عفونی
کد شناسایی :8474
ارائه شده توسط : دکتر فیروز امانی
ارائه شده در تاریخ :10 بهمن 1395 08:23
آخرین تغییر :21 اردبهشت 1399 16:18

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