تاثیر دسفرال وریدی همراه با ترانسفیوزن خون در کاهش سطح سرمی فریتین در بیماران با تالاسمی ماژور(2017)

فتحی, افشین and امانی, فیروز and عرقچین, سمیرا and فرزانه, اسماعیل (1395) تاثیر دسفرال وریدی همراه با ترانسفیوزن خون در کاهش سطح سرمی فریتین در بیماران با تالاسمی ماژور(2017). International Journal of Basic & Clinical Pharmacology ــ 6 (2). pp. 399-403. شاپا 2003-2319


Official URL: http://www.ijbcp.com/index.php/ijbcp


Effect of intravenous Deferoxamine concomitant use with blood transfusion on serum ferritin in thalassemia major patients

English Abstract

Background: Subcutaneous Deferoxamineis often not tolerated by patients and its rejection leads to iron overload with its complications. So, other methods with better toleration and reduction of Deferoxamine consumption are necessary. The present study aimed to evaluate the effect of intravenous Deferoxamine infusion during blood transfusion on serum ferritin (SF) in thalassemia major patients. Methods: In a retrospective cross-sectional study, thirty four patients with β-thalassemia major treated with monthly blood transfusion at Bu-Ali hospital in Ardabil city from April 2013 to April 2014, were selected and followed for six months. The mean SF rate and the needed subcutaneous Deferoxamine rates before intervention were considered as baseline. All patients received intravenous Deferoxamine concomitant with their routine monthly blood transfusion for six months. After six months mean values for ferritin, subcutaneous Deferoxamine were compared with baseline values. Collected data were analyzed using t-test and paired t-test by SPSS, version 18.P<0.05 was considered as significant. Results: Compared with baseline, the subcutaneous Deferoxamine rate and ferritin level have been decreased significantly after intervention. Conclusions: Intravenous Deferoxamine concomitant use with routine monthly blood transfusion in thalassemia major patients can lead to decreasing of ferritin level. With this method, patient care could be improved, health care costs and complications of treatment effectively reduced.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :افشین فتحی
نویسنده :فیروز امانی
نویسنده مسئول :اسماعیل فرزانه
Additional Information:Indexed in: Index Copernicus
کلیدواژه ها (انگلیسی):Beta-thalassemia, Blood transfusion, Deferoxamine
Subjects:WT Geriatrics . Chronic Diseases
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:8474
Deposited By: Dr Firouz Amani
Deposited On:10 Nov 1395 08:23
Last Modified:21 Feb 1399 16:18

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