تاثیر کوتاه مدت درمان ضد انعقادی داخل وریدی در بیماران با خونریزی داخل مغزی

قندهاری, کاویان and نیکخواه, کریم and برومند, امیررضا and حسینی نژاد, سید جواد and درخشان, سیاوش and ملت اردکانی, علی and فتاح زاده اردلانی, قاسم (1389) تاثیر کوتاه مدت درمان ضد انعقادی داخل وریدی در بیماران با خونریزی داخل مغزی. ARYA Atherosclerosis ــ 5 (2). pp. 81-84. شاپا 1735-3955


Official URL: http://www.arya.mui.ac.ir



English Abstract

BACKGROUND: Progressive stroke (PS) and Crescendo Transient Ischemic Attacks (CTIA) is a generally accepted although unproven, indication for urgent intravenous anticoagulation therapy. METHODS: Consecutive patients with PS and CTIA admitted in Ghaem hospital, Mashhad during 2007 - 2008 enrolled in a prospective clinical study. PS and CTIA patients underwent intravenous heparin therapy with 1000 units per hour without a bolus dose at least for 3 days. PS and CTIA patients who had a contraindication for intravenous hepain therapy, received 80 mg Aspirin per day. Early clinical course including improvement, stabilization, deterioration and development of residual stroke was evaluated in two therapeutic groups of PS and CTIA patients. RESULTS: 170 PS patients (103 males, 67 females) with mean age of 60.4 ± 12.3 years and 88 CTIA patients (50 males, 38 females) with mean age of 60.1 ± 6.8 years were assessed. 141 PS and 64 CTIA patients received short period intravenous heparinization. Distribution of subtypes of early clinical course between two therapeutic groups of PS and CTIA patients, was significantly different; X2 = 10.487, df = 2, p = 0.005 and X2 = 6.72, df = 2, p = 0.035 respectively. Distribution of residual stroke in two therapeutic groups of PS and CTIA patients,was not significantly different; X2 = 1.443, df = 1, p = 0.23, OR = 0.557 (0.212-1.462) and X2 = 1.01, df = 1, p = 0.315, OR = 0.617 (0.24-1.587) respectively. CONCLUSION: PS and CTIA patients who underwent short period intravenous heparin therapy have significantly more probability of improvement and less probability of deterioration in their early clinical course than PS and CTIA patients who received Aspirin therapy.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :کاویان قندهاری
نویسنده :قاسم فتاح زاده اردلانی
Additional Information:Indexed in: WHO/EMR/Index , Index Copernicus , Academic Search Complete EBSCO Publishing databases, Scientific Information Database , Magiran ,
کلیدواژه ها (انگلیسی):Progressive Stroke (PS), Crescendo TransientIschemic Attacks (CTIA), Intravenous anticoagulation therapy, Heparin therapy
Subjects:WL Nervous system
Divisions:Faculty of Medicine > Department of Surgery
ID Code:8502
Deposited By: Dr Firouz Amani
Deposited On:19 Nov 1395 10:12
Last Modified:19 Nov 1395 10:12

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