title

کریسین به عنوان یک عامل ضد سرطانی سمیت انتخابی خود را با مهار کمپکس های II و V میتوکندریایی در سلول های سرطانی CLL اعمال میکند.(2017)

سلیمی, احمد and حبیبی رودکنار, مهریار and صیدی, عنایت اله and صادقی, لیلا and محسنی, علیرضا and پیراحمدی, نهال and پوراحمد, جلال (1395) کریسین به عنوان یک عامل ضد سرطانی سمیت انتخابی خود را با مهار کمپکس های II و V میتوکندریایی در سلول های سرطانی CLL اعمال میکند.(2017). Cancer Investigation ــ online . pp. 174-186. شاپا 0735-7907

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Title

Chrysin as an Anti-Cancer Agent Exerts Selective Toxicity by Directly Inhibiting Mitochondrial Complex II and V in CLL B-lymphocytes

English Abstract

We investigated the effect of chrysin on isolated normal and chronic lymphocytic leukemia (CLL) B-lymphocytes and their isolated mitochondria. We report that a selective and significant increase in cytotoxicity, intracellular reactive oxygen species, mitochondrial membrane potential collapse, ADP/ATP ratio, caspase 3 activation and finally apoptosis in chrysin-treated CLL B- lymphocytes. Also we determined that chrysin selectively inhibits complex II and ATPases in cancerous mitochondria. In this study we proved that the ability of chrysin to promote apoptosis in CLL B-lymphocytes performed by selectively targeting of mitochondria. Our findings may provide a potential therapeutic approach for using chrysin to target mitochondria in CLL B-lymphocytes.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :احمد سلیمی
نویسنده مسئول :جلال پوراحمد
Additional Information:Impact Factor(2015) 2.231 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, EBSCOhost, EMBASE, International Atomic Energy Agency, CABI
کلیدواژه ها (انگلیسی):Chrysin, mitochondria, complex II, CLL, complex V
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:8544
Deposited By: دکتر احمد سلیمی
Deposited On:10 Dec 1395 10:54
Last Modified:09 May 1396 05:57

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