title

شناسایی عوامل موثر بر بقا با استفاده از مدل جنگل تصادفی بقا

ادهم, داود and عباسقلی زاده, ناطق and اباذری, مالک (1395) شناسایی عوامل موثر بر بقا با استفاده از مدل جنگل تصادفی بقا. Asian Pacific Journal of Cancer Prevention ــ 18 (1). pp. 129-134. شاپا 1513-7368

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Title

Prognostic Factors for Survival in Patients with Gastric Cancerusing a Random Survival Forest

English Abstract

Background: Gastric cancer is the fifth most common cancer and the third top cause of cancer related death with about 1 million new cases and 700,000 deaths in 2012. The aim of this investigation was to identify important factors for outcome using a random survival forest (RSF) approach. Materials and Methods: Data were collected from 128 gastric ancer patients through a historical cohort study in Hamedan-Iran from 2007 to 2013. The event under consideration was death due to gastric cancer. The random survival forest model in R software was applied to determine the key factors affecting survival. Four split criteria were used to determine importance of the variables in the model including log-rank,conversation?? of events, log-rank score, and randomization. Efficiency of the model was confirmed in terms of Harrell’s concordance index. Results: The mean age of diagnosis was 63 ±12.57 and mean and median survival times were 15.2 (95%CI: 13.3, 17.0) and 12.3 (95%CI: 11.0, 13.4) months, respectively. The one-year, two-year, and three-year rates for survival were 51%, 13%, and 5%, respectively. Each RSF approach showed a slightly different ranking order. Very important covariates in nearly all the 4 RSF approaches were metastatic status, age at diagnosis and tumor size. The performance of each RSF approach was in the range of 0.29-0.32 and the best error rate was obtained by the log-rank splitting rule; second, third, and fourth ranks were log-rank score, conservation of events, and the random splitting rule, respectively. Conclusion: Low survival rate of gastric cancer patients is an indication of absence of a screening program for early diagnosis of the disease. Timely diagnosis in early phases increases survival and decreases mortality.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :داود ادهم
نویسنده :ناطق عباسقلی زاده
نویسنده مسئول :مالک اباذری
Additional Information:Indexed in: Pubmed/Medline/Undex Medicus, Scopus, Index Copernicus, EMBASE , DOAJ
کلیدواژه ها (انگلیسی):Gastric cancer- random survival forest- Hamadan-Iran
Subjects:WA Public Health > WA. 900 Vital Statistics
WA Public Health > WA. 900 Vital Statistics

WA Public Health
WA Public Health
Divisions:Faculty of Health > Health Management
Faculty of Health > Department of Statistics
Faculty of Health > Department of Public health
Faculty of Health > Department of Public health
Faculty of Health > Department of Public health
ID Code:8586
Deposited By: mr malek abazari
Deposited On:08 Jan 1396 04:37
Last Modified:26 Jan 1397 11:07

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