تاثیر دوز پایین متو مایسین در درمان svk

اوجاقی, حبیب and معصومی, رحیم and نوتاراج, حمید (1396) تاثیر دوز پایین متو مایسین در درمان svk. International journal of ophthalmic research ــ 3 (1). pp. 214-216. شاپا 2409-5680


Official URL: http://www.ghrnet.org/index.php/IJOR/index


Low-dose Topical Mitomycin-C in the Treatment of Severe Vernal Keratoconjunctivitis

English Abstract

BACKGROUND: Corticosteroids and mast–cell stabilizers are commonly used in treatment of vernal keratoconjunctivitis (V.K.C), but regarding the side – effects of the agents and poor response in severe cases, the aim of this study was to investigate the effect of low dose topical mitomycin- c 0.01% in the treatment of severe vernal keratoconjunctivitis. METHODS: In a double blind randomized clinical trial, 40 patients with V.K.C were randomly assigned to two equal size groups. One group received topical 0.01% Mitomycin-C and another group received placebo. Complaints (tearing, itching, and mucosal discharge) and symptoms (papillae, Micropannus, hyper injection, corneal and limbus involvement) were assessed at the baseline and 2 weeks after treatment in two groups. Data were analyzed by statistical methods in SPSS.16. RESULT: 40 patients were studied including 31 male and 9 female with average of 14.7 ± 3.8 years in case group and 16.2 ± 8.4 in control group. The mean disease duration in case group was 3.5 ± 3.2 years and in control group was 15 ± 4.6. Comparing the severity of complaints and symptoms two weeks after treatment in two groups, there was a statistically significant difference in the tearing (p = 0.029) and the size of papillae (p = 0.006). There wasn’t significant difference on other complaints and symptoms between two groups and no adverse effects of treatment with Mitomycin-C were observed. CONCLUSION: This study showed that use of topical mitomycin-C 0.01% along with usual routine drugs reduces the severity of tearing and the size of papillae and it may be considered as a conventional treatment on patients with severe V.K.C.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :حبیب اوجاقی
نویسنده مسئول :رحیم معصومی
نویسنده :حمید نوتاراج
Additional Information:Indxed in: Google Scholar
کلیدواژه ها (انگلیسی):Vernal keratoconjunctivitis; Mitomycin-C; Mast–cell stabilizers
Subjects:WW Ophthalmology
Divisions:Faculty of Medicine > Department of Surgery
ID Code:8607
Deposited By: Dr Firouz Amani
Deposited On:16 Jan 1396 08:11
Last Modified:16 Jan 1396 08:11

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