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تاثیر دوز پایین متو مایسین در درمان svk

اوجاقی, حبیب ، معصومی, رحیم ، نوتاراج, حمید (1396) تاثیر دوز پایین متو مایسین در درمان svk. International journal of ophthalmic research ــ 3 (1). ص.ص.214-216. شاپا 2409-5680

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آدرس اینترنتی رسمی : http://www.ghrnet.org/index.php/IJOR/index


عنوان انگليسي

Low-dose Topical Mitomycin-C in the Treatment of Severe Vernal Keratoconjunctivitis

خلاصه انگلیسی

BACKGROUND: Corticosteroids and mast–cell stabilizers are commonly used in treatment of vernal keratoconjunctivitis (V.K.C), but regarding the side – effects of the agents and poor response in severe cases, the aim of this study was to investigate the effect of low dose topical mitomycin- c 0.01% in the treatment of severe vernal keratoconjunctivitis. METHODS: In a double blind randomized clinical trial, 40 patients with V.K.C were randomly assigned to two equal size groups. One group received topical 0.01% Mitomycin-C and another group received placebo. Complaints (tearing, itching, and mucosal discharge) and symptoms (papillae, Micropannus, hyper injection, corneal and limbus involvement) were assessed at the baseline and 2 weeks after treatment in two groups. Data were analyzed by statistical methods in SPSS.16. RESULT: 40 patients were studied including 31 male and 9 female with average of 14.7 ± 3.8 years in case group and 16.2 ± 8.4 in control group. The mean disease duration in case group was 3.5 ± 3.2 years and in control group was 15 ± 4.6. Comparing the severity of complaints and symptoms two weeks after treatment in two groups, there was a statistically significant difference in the tearing (p = 0.029) and the size of papillae (p = 0.006). There wasn’t significant difference on other complaints and symptoms between two groups and no adverse effects of treatment with Mitomycin-C were observed. CONCLUSION: This study showed that use of topical mitomycin-C 0.01% along with usual routine drugs reduces the severity of tearing and the size of papillae and it may be considered as a conventional treatment on patients with severe V.K.C.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :حبیب اوجاقی
نویسنده مسئول :رحیم معصومی
نویسنده :حمید نوتاراج
اطلاعات اضافی :Indxed in: Google Scholar
کلیدواژه ها (انگلیسی):Vernal keratoconjunctivitis; Mitomycin-C; Mast–cell stabilizers
موضوعات :WW چشم پزشکی
بخش های دانشگاهی :دانشكده پزشكي > گروه جراحی
کد شناسایی :8607
ارائه شده توسط : دکتر فیروز امانی
ارائه شده در تاریخ :16 فروردین 1396 08:11
آخرین تغییر :16 فروردین 1396 08:11

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