مطالعه بر روی خصوصیات نانوذرات طلا به عنوان ماده حاجب در تصویر برداری سی تی اسکن

مصباحی, اصغر and فاموری, فاطمه and جوهری اهر, محمد and اولاد غفاری, مریم and قوامی, سید مصطفی (1396) مطالعه بر روی خصوصیات نانوذرات طلا به عنوان ماده حاجب در تصویر برداری سی تی اسکن. Polish Journal of Medical Physics and Engineering ــ 23 (1). pp. 9-14. شاپا 1898-0309

Text - Published Version

Official URL: https://www.degruyter.com/view/j/pjmpe


A study on the imaging characteristics of Gold nanoparticles as a contrast agent in X-ray computed tomography

English Abstract

Aim: In the current study, some imaging characteristics of AuNPs were quantitatively analyzed and compared with two conventional contrast media (CM) including Iodine and Gadolinium by using of a cylindrical phantom. Methods: AuNPs were synthesized with the mean diameter of 16 nm and were equalized to the concentration of 0.5, 1, 2 and 4 mg/mL in the same volumes. A cylindrical phantom resembling the head and neck was fabricated and drilled to contain small tubes filled with Iodine, Gadolinium, and AuNPs as contrast media. The phantom was scanned in different exposure techniques and CT numbers of three studied contrast media inside test tubes were measured in terms of Hounsfield Unit (HU). The imaging parameters of the noise and contrast to noise ratios (CNR) were calculated for all studied CMs. Results: AuNPs showed 128% and 166% higher CT number in comparison with Iodine and Gadolinium respectively. Also, Iodine had a greater CT number than Gadolinium for the same exposure techniques and concentration. The maximum CT number for AuNPs and studied contrast materials was obtained at the highest mAs and the lowest tube potential. The maximum CT number were 1033±11 (HU) for AuNP, 565±10 (HU) for Iodine, 458±11 for Gadolinium. Moreover, the maximum CNRs of 433±117, 203±53, 145±37 were found for AuNPs, Iodine and Gadolinium respectively. Conclusion: The contrast agent based on AuNPs showed higher imaging quality in terms of contrast and noise relative to other iodine and gadolinium based contrast media in X-ray computed tomography. Application of the AuNPs as a contrast medium in x-ray CT is recommended.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :اصغر مصباحی
نویسنده :محمد جوهری اهر
نویسنده مسئول :سید مصطفی قوامی
Additional Information:Indexed in: Scopus, Arianta, Astrophysics Data System (ADS), Baidu Scholar, Case, EBSCO, EMBASE, Reaxys, Google Scholar, J-Gate, Polish Medical Bibliography/Polish Medical Library, Polish Scientific Journals Database, ProQuest, ReadCube, SCImago (SJR)
کلیدواژه ها (انگلیسی):AuNP , contrast media , X-ray computed tomography , nanoparticle
Subjects:WN Radiology . Diagnostic Imaging
Divisions:School of Pharmacy > Department of Medicinal Chemistry
ID Code:8611
Deposited By: Dr Mohammad Johari-Ahar
Deposited On:02 Feb 1396 05:59
Last Modified:02 Feb 1396 05:59

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