اولین گزارش از دو مورد هپاتیت منتهی به مرگ در بیماران مسلول مبتلا به کمبود آلفا 1 آنتی تریپسین

حبیب زاده, شهرام and محمدشاهی, جعفر and قبادی مراللو, حسن and ملکی, نصراله (1396) اولین گزارش از دو مورد هپاتیت منتهی به مرگ در بیماران مسلول مبتلا به کمبود آلفا 1 آنتی تریپسین. The International Journal of Mycobacteriology ــ 6 (2). pp. 187-190. شاپا 2212-5531


Official URL: http://www.ijmyco.org


The First Report of Two Cases of Fatal Liver Injury Dueto Anti‑tuberculosis Drugs in the Presence of Alpha‑1Antitrypsin Deficiency

English Abstract

Tuberculosis (TB) is a major global health problem. Awareness of liver injury due to anti-TB therapy is vital because fulminant hepatic failure is a devastating and often fatal condition without liver transplantation. Here, we report for the first time, two patients of fatal liver injury due to anti-TB drugs in the presence of alpha-1 antitrypsin deficiency. Based on the triad of rapid loss in hepatocyte function, the onset of hepatic encephalopathy, and absence of a prior history of liver disease, the diagnosis of acute liver failure was established. Both patients had low levels of serum alpha-1 antitrypsin, consistent with alpha-1 antitrypsin deficiency. Despite aggressive medical therapy and supportive care, patients developed multi-organ failure and died. It seems measuring the serum levels of alpha 1-antitrypsin before beginning anti-TB therapies is necessary, especially when there is emphysema or bronchiectasis.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :شهرام حبیب زاده
نویسنده :جعفر محمدشاهی
نویسنده :حسن قبادی مراللو
نویسنده مسئول :نصراله ملکی
Additional Information:Indexed in: PubMed/Medline, Scopus, ESCI, EMBASE
کلیدواژه ها (انگلیسی):Alpha1‑antitrypsin deficiency, anti‑tuberculosis drugs, death, hepatitis
Subjects:WC Communicable Diseases
WF Respiratory System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:8747
Deposited By: Dr Shahram Habibzadeh
Deposited On:02 Mar 1396 04:26
Last Modified:23 Dec 1401 09:58

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