L-سیستئین مهارکننده قوی گلیکه شدن آلبومین وLDL و پیشگیرنده اختلالات دیابتی در موش صحرایی دیابتی-آتروسکلروزی

مهدوی فرد, سیدسینا/ صفدر and بطحایی, سیده زهرا and نخجوانی, منوچهر and حیدر زاده, حمید (1393) L-سیستئین مهارکننده قوی گلیکه شدن آلبومین وLDL و پیشگیرنده اختلالات دیابتی در موش صحرایی دیابتی-آتروسکلروزی. Food Research International ــ 62 . pp. 909-916. شاپا 0963-9969

Text - Published Version

Official URL: http://www.sciencedirect.com/science/journal/02235...


L-cysteine is a potent inhibitor of protein glycation on both albumin and LDL, and prevents the diabetic complications in diabetic-Atherosclerotic rat

English Abstract

The aim of the present study is to investigate the protective effect of L-cysteine (Cys) on protein glycation, and hence, the improvement of diabetic complications. Streptozotocin-induced diabetic rats on an atherogenic diet were used as a model. Two groups of rats, normal and diabetic, were treated with 0.05% of Cys in drinking water for 3 months and two others received water only. Some parameters including: glucose, insulin, glycation products, activity of the glyoxalase system, lipid profile, oxidation markers, high sensitivity CRP (Hs CRP) and creatinine in the serum, and protein in the urine of all rats were determined. Furthermore, rat serum albumin and LDL were purified and incubated with glucose in the presence and absence of Cys and the samples were investigated for glycation and oxidation products. Cys showed an inhibitory effect on glycation and oxidation products in both in vivo and in vitro conditions. It reduced glucose, insulin resistance, triglyceride, cholesterol, LDL, Hs CRP and creatinine in the serum; and the proteinuria; furthermore, it increased HDL and glyoxalase systemactivity in the serum of the diabetic–atherosclerotic rats. Cys reduced all of the risk factors of diabetic complications and showed anti-atherosclerotic potential; thus it is useful in diabetes treatment.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سیدسینا/ صفدر مهدوی فرد
نویسنده مسئول :سیده زهرا بطحایی
Additional Information:Impact Factor (2014) 2.818 Indexed in: ISI, Scopus, Chemical Abstracts, BIOSIS, Current Contents/Agriculture,
کلیدواژه ها (انگلیسی):Glycation Products; Proteinuria; Oxidation products; Rat serum albumin; Sterptozotocin; Atherogenic diet
Subjects:QU Biochemistry
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
ID Code:8754
Deposited By: Dr Sina Mahdavifard
Deposited On:09 Mar 1396 08:09
Last Modified:26 Jan 1400 12:39

Repository Staff Only: item control page

Document Downloads

More statistics for this item...