title

اثر شل کنندگی گیاه مرزه بر روی زنجیره تراشه خوکچه هندی و مکانیسم احتمالی آن

بسکابادی, محمد حسین and اصلانی, محمدرضا and منصوری, فاطمه and عامری, صدیقه (1386) اثر شل کنندگی گیاه مرزه بر روی زنجیره تراشه خوکچه هندی و مکانیسم احتمالی آن. DARU Journal of Pharmaceutical Sciences ــ 15 (4). pp. 199-204. شاپا 1560-8115

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Title

Relaxant effect of Satureja hortensis on guinea pig tracheal chains and its possible mechanism(s)

English Abstract

Background: In Iranian ancient medical books, the therapeutic effects of Satureja hortensis on respiratory diseases have been reported. In order to verify these reports, the relaxant effect of aqueous-ethanolic extract of Satureja hortensis on guinea pig trachea was examined. Methods: The relaxant effects of 6 cumulative concentrations of extract (0.15, 0.3, 0.45, 0.6, 0.75 and 0.9 g %) in comparison with saline and 4 cumulative concentrations of theophylline (0.15, 0.3, 0.45, and 0.6 mM) by their effects on precontracted tracheal chains of guinea pig by 10 μM methacholine (group 1) or 60 mM KCl in two different conditions including: non-incubated tissues (group 2) and incubated tissues with 1 μM propranolol, 1 μM chlorpheniramine and 1 μM atropine (group 3, for each group n=6) were examined. Results: In group 1, the extract and theophylline showed concentration dependent relaxant effects compared to that of saline (p<0.05 to p<0.001). In group 2, three last concentrations of theophylline and four higher concentrations of extract showed significant relaxant effects compared to that of saline (p<0.05 to p<0.001). The effects of four lower concentrations of extracts in groups 1 and 2 were significantly lower than those of theophylline (p<0.05 p<0.001). In group 3, the extract did not show any significant relaxant effect. There were significant correlations between the relaxant effects and concentrations of extract and theophylline in groups 1 and 2 (p<0.001 for all cases). Conclusion: These results showed a potent relaxant effect of Satureja hortensis on guinea pigs trachea which was comparable to that of theophylline.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :محمد حسین بسکابادی
نویسنده :محمدرضا اصلانی
نویسنده :فاطمه منصوری
نویسنده :صدیقه عامری
Additional Information:Indexed in: Scopus
کلیدواژه ها (انگلیسی):Satureja hortensis . Bronchodilatory . Guinea pig. Trachea
Subjects:QT physiology
WF Respiratory System
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:8807
Deposited By: Dr Mohammad Reza Aslani
Deposited On:03 May 1396 06:36
Last Modified:26 Jun 1402 14:24

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