اثرات حفاظتی کوآنزیم Q10 بر آسیب ایسکمی-ریپرفیوژن عضله اسکلتی از طریق NF-kappa B صورت می گیرد

بیگی بروجنی, ماندانا and خانی پور خیاط, زهرا and عنبری, خاطره and نیاپور, علی and غلامی, محمد رضا and محمد غراوی, آنه (1396) اثرات حفاظتی کوآنزیم Q10 بر آسیب ایسکمی-ریپرفیوژن عضله اسکلتی از طریق NF-kappa B صورت می گیرد. Perfusion ــ 32 (5). pp. 372-377. شاپا 0267-6591

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Official URL: http://journals.sagepub.com/toc/PRF/current


Coenzyme Q10 protects skeletal muscle from ischemia-reperfusion through the NF-kappa B pathway.

English Abstract

OBJECTIVE: Coenzyme Q10 (CoQ10) has antioxidant and anti-inflammatory activity. The aim of this study was to investigate the effects of CoQ10 on the inhibition of nuclear factor-kappa B (NF-κB) activation during ischemia-reperfusion (I/R) of skeletal muscle. METHODS: For ischemia induction, the animals were anesthetized and the external iliac vessels blocked for three hours. CoQ10 or vehicle was given intraperitoneally during ischemia, just before reperfusion. Four groups received 3,7,14 and 28 days' reperfusion, respectively, after the intraperitoneal injection of CoQ10 and four corresponding groups received vehicle only. After reperfusion, the gastrocnemius muscles were removed, fixed and stained for the analysis of edema and mast cell infiltration. RESULTS: Immuno-histochemistry staining was performed for the detection of tumor necrosis factor alpha (TNF-α) and NF-κB. CoQ10-treated groups showed a significant decrease of mast cell infiltration in the gastrocnemius muscle and edema as compared with the corresponding non-treated groups. Also, CoQ10-treated groups showed a significant TNF-α and NF-κB expression decrease when compared to the corresponding non-treated controls. The results of this study showed CoQ10 administration with ischemia decreased interstitial edema, degeneration of muscle fibers and infiltration of mast cells. CONCLUSIONS: It seems that CoQ10 has inhibitory effects on NF-κB and TNF-α activation.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :ماندانا بیگی بروجنی
نویسنده :زهرا خانی پور خیاط
نویسنده :خاطره عنبری
نویسنده :علی نیاپور
نویسنده مسئول :محمد رضا غلامی
نویسنده :آنه محمد غراوی
Additional Information:IF: 0.95 Indexed in: ISI, PubMed/Medline , Scopus
کلیدواژه ها (انگلیسی):NF-κB; TNF-α; coenzyme Q10; edema; ischemia-reperfusion
Subjects:QS Human Anatomy
QT physiology
QV pharmacology
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Anatomy
ID Code:8894
Deposited By: Dr Ali Niapour
Deposited On:28 Mar 1396 05:16
Last Modified:29 May 1401 10:10

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