فکرآزاد, رضا ، پورستاربجه میر, آرش ، کهیایی اقدم, مینا ، قاسمی برقی, ودود (1396) مقايسه اثر بخشی دو روش فوتودینامیک تراپی توسط نیو متیلن بلو و ایندوسیانین سبز ضد میکروبی بر روی تریکوفیتون روبروم درمحیط آزمایشگاهی. Photodiagnosis and Photodynamic Therapy ــ 18 . ص.ص.208-212. شاپا 1572-1000
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آدرس اینترنتی رسمی : http://www.sciencedirect.com/science/journal/15721...
عنوان انگليسی
Comparison of photoinactivation of T. rubrum by new methylene blue(NMB) and indocyanine green (EmunDo®)
خلاصه انگلیسی
Background: Superficial mycotic skin infections which are predominantly caused by Trichophyton rubrum,poorly responsd to conventional therapies. A great amount of attention has focused on finding moreeffective treatments. The current work is aimed to compare the effectiveness of phoinactivation of Tri-chophyton rubrum by two relatively new photosensitizers: a phenothiazinium dye(New methylene blue)and Indocyanine green (EmunDo®).Materials and methods: A Final inoculum of T. rubrum which corresponded to 106colony forming unitper milliliter (CFU ml−1) was prepared. Antimicrobial Photodynamic treatment (aPDT) of T. rubrum wascarried out by either EmunDo®(1 mg/ml, Infra-red laser (IRL, � = 810 nm, Energy Density 55 J/cm2)) orNMB (10 �M, Red laser (RL), � = 630 nm, Energy Density of 5 J/cm2). The suspensions thereafter weresubcultured on Sabouraud dextrose agar (SDA) and were counted on due time. based on colony-formingunit per milliliter (CFU/ml).Results: aPDT with either EmunDo®(E) or NMB (N) considerably diminished the viability of inoculatedT. rubrum with respective reduction of 0.64 log and 0.4 log compared to the control group (P < 0.001). Nosignificant difference was found between two laser only groups (P = 0.79) and two aPDT groups (P = 0.73),however significant reduction of T. rubrum in red laser only group (P = 0.04) and EmunDo®only group(P = 0.04) was found as compared to the control group (P < 0.05).Conclusion: The study provides evidence regarding satisfactory photodynamic inactivation of T. rubrumwith EmunDo®or NMB as photosensitizers. Irradiation by only red laser source was found superior toonly infra-red laser source. Dark toxicity of EmunDo®was more successful than new methylene bluedye.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | رضا فکرآزاد |
نویسنده : | آرش پورستاربجه میر |
نویسنده مسئول : | مینا کهیایی اقدم |
نویسنده : | ودود قاسمی برقی |
ضریب تاثیر و نمایه مجلات: | Impact Factor(2016) 2.219 Indexed in: ISI, Pubmed/ Medline/Index Medicus, Scopus, National Library of Medicine, ScienceDirect |
کلیدواژه ها (انگلیسی): | Photoinactivation, Photosensitizer, Trichophyton rubruma |
موضوعات : | WR بیماریهای پوست |
بخش های دانشگاهی : | دانشکده دندانپزشکی > گروه جراحی دهان، فک و صورت |
کد شناسایی : | 8927 |
ارائه شده توسط : | دکتر ودود قاسمی برقی |
ارائه شده در تاریخ : | 03 تیر 1396 10:00 |
آخرین تغییر : | 03 تیر 1396 10:00 |
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