ترکیب اثر آنتی اکسیدانی اریتروپویتین و ملاتونین بر آسیب کلیه ناشی از ایسکمی-رپرفیوژن در موشهای صحرائی نر

بنایی, شکوفه and احمدی اصل, ناصر and عظیمیان, احسان (1392) ترکیب اثر آنتی اکسیدانی اریتروپویتین و ملاتونین بر آسیب کلیه ناشی از ایسکمی-رپرفیوژن در موشهای صحرائی نر. در: 21st international iranian congress of physiology and pharmacology, Aug 23-27 , 2013, Tabriz-Iran.



Combination antioxidant effect of erythropoietin and melatonin on renal ischemia reperfusion damage in male rats

English Abstract

Ischemia reperfusion (IR) contributes to acute renal failure (ARF). Oxygen free radicals are involved in pathophysiology of ischemia reperfusion injury (IRI). This study was designed to investigate the effects of erythropoietin (EPO) and melatonin (MEL), which are known antiinflammatory and antioxidant agents, in IR-induced renal injury in rats. Male Wistar Albino rats were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 24 h of reperfusion. MEL (10mg/kg, i.p) and EPO (5000U/kg, i.p) were administered prior to ischemia. After 24 h of the reperfusion, kidneys were removed and weighted, blood samples were collected for the determination of total antioxidant capacity (TAC), cholesterol and uric acid levels. The level of malondialdehyde (MDA) was measured in renal samples. Treatment with EPO or MEL had a curative effect on renal IR injury. The EPO+MEL group showed significantly greater improvement on renal weight and TAC levels when compared with the other treatment groups, moreover, this group significantly decreased MDA, cholesterol and uric acid levels. Our results indicate that the combination of erythropoietin and melatonin may exert more beneficial effects than either agent used alone

Item Type:Conference or Workshop Item (Speech)
زبان سند : انگلیسی
نویسنده اول :شکوفه بنایی
نویسنده :ناصر احمدی اصل
نویسنده :احسان عظیمیان
کلیدواژه ها (انگلیسی):ischemia reperfusion injury, antioxidant, melatonin, erythropoietin, lipid peroxidation, kidney.
Subjects:QT physiology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:8936
Deposited By: Dr shokofeh banaei kivi
Deposited On:04 Apr 1396 08:54
Last Modified:04 Apr 1396 08:54

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