ژنوتایپ های هلیکوباکتر پیلوری خطر ابتلا به سرطان معده نوع نان-کاردیا و نوع روده ای یا دیفیوز در اردبیل را تعیین می کنند: یک منطقه بسیار خطرناک در شمال غربی ایران

عبدی, عصمت and لطیفی نوید, سعید and زهری, صابر and یزدانبد, عباس and صفرعلی زاده, رضا (1396) ژنوتایپ های هلیکوباکتر پیلوری خطر ابتلا به سرطان معده نوع نان-کاردیا و نوع روده ای یا دیفیوز در اردبیل را تعیین می کنند: یک منطقه بسیار خطرناک در شمال غربی ایران. Microbial Pathogenesis ــ 107 . pp. 287-292. شاپا 0882-4010

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Helicobacter pylori genotypes determine risk of non-cardia gastric cancer and intestinal- or diffuse-type GC in Ardabil: A very high-risk area in Northwestern Iran

English Abstract

Frequency of the Helicobacter pylori vacA gene polymorphism and its association with gastric cancer (GC) was assessed in Ardabil, a very high-risk area in Northwestern Iran. We determined the presence of the H. pylori 16S rDNA gene and the vacA s-, m-, i-, and d-region genotypes in DNA from fresh gastric biopsies. Patients with GC were classified based on both the anatomic site and the histopathologic type of tumor Of 135 patients, including 57 with non-atrophic gastritis (NAG) and 78 with GC, 103 were infected by H. pylori. The vacA i1 and d1 genotypes were significantly linked to an increased risk of GC, where both cardia (CGC) and non-cardia GC (NCGC) patients were entered into the analysis. The adjusted OR was 9.59 for i1 and 4.39 for d1. Furthermore, i1 was significantly linked to an increased risk of the intestinal-type adenocarcinoma (OR = 14.04) and d1 to the risk of the diffuse-type adenocarcinoma (OR = 7.71). The presence of the m1-type of vacA in combination with i1 or d1 further increased the risk of GC. When the analysis was restricted to NCGC, the adjusted OR for i1 and d1, was 37.52 and 7.17, respectively. No significant association was found between genotypes and the risk of GC in the cardia site of the stomach. It is proposed that the new types of H. pylori vacA, i1 and d1, might be important determinants of NCGC risk in Ardabil. The m1, not independently, but in combination might further define the risk of GC. i1and d1 might also predict the risk of the intestinal- and diffuse-type adenocarcinomas, respectively.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :عصمت عبدی
نویسنده مسئول :سعید لطیفی نوید
نویسنده :صابر زهری
نویسنده :عباس یزدانبد
نویسنده :رضا صفرعلی زاده
Additional Information:Impact Factor (2016) 2.009 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts, BIOSIS, Current Contents/Life Sciences, Immunology Abstracts, Microbiology Abstracts, Genetics Abstracts, Reference Update, Research Alert, SCISEARCH, Biological Abstracts
کلیدواژه ها (انگلیسی):H. pyloriGenotypesGastric cancerDiffuse-type adenocarcinomasIntestinal-type adenocarcinomasArdabil
Subjects:QU Biochemistry
QW Microbiology and Immunology
WI Digestive System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:8986
Deposited By: Dr Nasrollah Maleki
Deposited On:28 Apr 1396 06:31
Last Modified:28 Apr 1396 06:31

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