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نقش مؤثر مس در کمبود حافظه فضایی ناشی از بتا آمیلوئید و ارزیابی نشانگرهای عملکرد میتوکندری در هیپوکامپ موش صحرایی

بهزاد فر, لادن and عبدالهی, محمد and سبزواری, امید and حسینی, روح اله and سلیمی, احمد and ناصر زاده, پروانه and شریف زاده, محمد and پوراحمد, جلال (1396) نقش مؤثر مس در کمبود حافظه فضایی ناشی از بتا آمیلوئید و ارزیابی نشانگرهای عملکرد میتوکندری در هیپوکامپ موش صحرایی. Metallomics ــ 9 (7). pp. 969-980. شاپا 1756-591X

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Official URL: http://pubs.rsc.org/en/content/articlelanding/2017...


Title

Potentiating role of copper on spatial memory deficit induced by beta amyloid and evaluation of mitochondrial function markers in the hippocampus of rats

English Abstract

Mounting evidence suggests that copper, a crucial element in normal brain function, plays an important role in the etiology of Alzheimer’s disease, which is known as a neurodegenerative mitochondrial disorder. However, the precise mechanisms of its effects on cognitive and mitochondrial functions through the CNS have not been thoroughly recognized yet. In this study, we aimed to investigate the long-term (3-week) effects of copper sulfate (50, 100 and 200 mg kg1 day1) exposure on learning and memory as well as on mitochondrial function in the hippocampus of rats in the presence and absence of beta amyloid (1 mg ml1 per side) intrahippocampally (IH). After three weeks of copper exposure through drinking water, acquisition and retention of spatial memory were measured by the Morris water maze (MWM) test. Various parameters of mitochondrial function were also evaluated. Our data show that copper damaged the spatial learning and memory and also exacerbated the memory deficit induced by Ab injection in rats in a dose-dependent manner. Mitochondria isolated from the hippocampus of rats treated with copper showed significant increases in ROS formation, mitochondrial swelling, lipid peroxidation, glutathione oxidation, outer membrane damage, and collapse of MMP, decreased cytochrome c oxidase activity, and finally increased ADP/ATP ratios. Our results indicate that copper overloading in the hippocampus of rats causes mitochondrial dysfunction and subsequent oxidative stress leading to cognitive impairment. This study also reveals that copper can potentiate Ab deleterious effects on spatial memory and brain mitochondrial function.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :لادن بهزاد فر
نویسنده :احمد سلیمی
نویسنده مسئول :محمد شریف زاده
نویسنده مسئول :جلال پوراحمد
Additional Information:Impact Factor(2016) 3.975 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts, British Library
کلیدواژه ها (انگلیسی):Copper, Beta Amyloid, Mitochondria, Hippocampus
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:8992
Deposited By: دکتر احمد سلیمی
Deposited On:31 Apr 1396 07:04
Last Modified:24 Mar 1397 11:28

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