نانوذرات کربن تک لایه، چند لایه و Fe2O3 سب القاء آپوپتوز از مسیر میتوکندریایی در سلول های ملانوم پوستی می شوند

ناصر زاده, پروانه and انصاری, فاطمه and کاویانی, محبوبه and اشتری, خدیجه and خیربخش, راحله and سلیمی, احمد and پوراحمد, جلال (1397) نانوذرات کربن تک لایه، چند لایه و Fe2O3 سب القاء آپوپتوز از مسیر میتوکندریایی در سلول های ملانوم پوستی می شوند. Cutaneous and Ocular Toxicology ــ 37 (2). pp. 157-166. شاپا 1556-9527

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Official URL: http://www.tandfonline.com/doi/full/10.1080/155695...


Single-walled carbon nanotube, multi-walled carbon nanotube and Fe2O3 nanoparticles induced mitochondria mediated apoptosis in melanoma cells

English Abstract

Purpose: Nanomaterials (NM) exhibit novel anticancer properties. Materials and methods: The toxicity of three nanoparticles that are currently being produced in high tonnage including single-walled carbon nanotube (SWCNT), multi-walled carbon nanotube (MWCNT) and Fe2O3 nanoparticles, were compared with normal and melanoma cells. Results: All tested nanoparticles induced selective toxicity and caspase 3 activation through mitochondria pathway in melanoma cells and mitochondria cause the generating of reactive oxygen species (ROS), mitochondrial membrane potential decline (MMP collapse), mitochondria swelling, and cytochrome c release. The pretreatment of butylated hydroxytoluene (BHT), a cell-permeable antioxidant and cyclosporine A (Cs. A), a mitochondrial permeability transition (MPT), pore sealing agent decreased cytotoxicity, caspase 3 activation, ROS generation, and mitochondrial damages induced by SWCNT, MWCNT, and IONPs. Conclusions: Our promising results provide a potential approach for the future therapeutic use of SWCNT, MWCNT, and IONPs in melanoma through mitochondrial targeting.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :پروانه ناصر زاده
نویسنده :فاطمه انصاری
نویسنده :محبوبه کاویانی
نویسنده :خدیجه اشتری
نویسنده :راحله خیربخش
نویسنده مسئول :احمد سلیمی
نویسنده مسئول :جلال پوراحمد
Additional Information:IF: 1.079 Indexed in: ISI, PubMed/Medline, Scopus, EMBASE
کلیدواژه ها (انگلیسی):SWCNT; MWCNT; Fe2O3 nanoparticles; melanoma; mitochondria
Subjects:QV pharmacology > QV 600 Toxicology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:9104
Deposited By: Dr Ahmad Salimi
Deposited On:06 Jun 1396 07:37
Last Modified:24 Jan 1401 10:32

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