title

نانوذرات کربن تک لایه، چند لایه و Fe2O3 سب القاء آپوپتوز از مسیر میتوکندریایی در سلول های ملانوم پوستی می شوند

ناصر زاده, پروانه and انصاری, فاطمه and کاویانی, محبوبه and اشتری, خدیجه and خیربخش, راحله and سلیمی, احمد and پوراحمد, جلال (1396) نانوذرات کربن تک لایه، چند لایه و Fe2O3 سب القاء آپوپتوز از مسیر میتوکندریایی در سلول های ملانوم پوستی می شوند. Cutaneous and Ocular Toxicology ــ online . شاپا 1556-9527

[img] Text
محدود به Repository staff only

2MB

Official URL: http://www.tandfonline.com/doi/full/10.1080/155695...


Title

Single-walled carbon nanotube, multi-walled carbon nanotube and Fe2O3 nanoparticles induced mitochondria mediated apoptosis in melanoma cells

English Abstract

Purpose: Nanomaterials (NM) exhibit novel anticancer properties. Materials and methods: The toxicity of three nanoparticles that are currently being produced in high tonnage including single-walled carbon nanotube (SWCNT), multi-walled carbon nanotube (MWCNT) and Fe2O3 nanoparticles, were compared with normal and melanoma cells. Results: All tested nanoparticles induced selective toxicity and caspase 3 activation through mitochondria pathway in melanoma cells and mitochondria cause the generating of reactive oxygen species (ROS), mitochondrial membrane potential decline (MMP collapse), mitochondria swelling, and cytochrome c release. The pretreatment of butylated hydroxytoluene (BHT), a cell-permeable antioxidant and cyclosporine A (Cs. A), a mitochondrial permeability transition (MPT), pore sealing agent decreased cytotoxicity, caspase 3 activation, ROS generation, and mitochondrial damages induced by SWCNT, MWCNT, and IONPs. Conclusions: Our promising results provide a potential approach for the future therapeutic use of SWCNT, MWCNT, and IONPs in melanoma through mitochondrial targeting.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :پروانه ناصر زاده
نویسنده مسئول :احمد سلیمی
نویسنده مسئول :جلال پوراحمد
Additional Information:Impact Factor (2016) 1.213 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts, BIOBASE, Biological Abstracts, BIOSIS Previews, EMBASE, EMBIOLOGY, Toxicology Abstracts CABI Global Health, Abstracts on Hygiene and Communicable Diseases, Agricultural Economics Database, Horticultural Science Abstracts, Horticultural Science Database, Nutrition Abstracts and Reviews Series A, Nutrition and Food Sciences Database
کلیدواژه ها (انگلیسی):SWCNT; MWCNT; Fe2O3 nanoparticles; melanoma; mitochondria
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:9104
Deposited By: دکتر احمد سلیمی
Deposited On:06 Jun 1396 07:37
Last Modified:20 Aug 1396 04:57

Repository Staff Only: item control page

Document Downloads

More statistics for this item...