title

Methylsulfonylmethane در مقابل آسیب موکوس معده موثر است

امیرشاهرخی, کیوان and خلیلی, علیرضا (1396) Methylsulfonylmethane در مقابل آسیب موکوس معده موثر است. European Journal of Pharmacology ــ 811 . pp. 240-248. شاپا 0014-2999

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Title

Methylsulfonylmethane is effective against gastric mucosal injury

English Abstract

Methylsulfonylmethane (MSM) is a natural organosulfur compound has been widely used as a dietary supplement. MSM has protective effects against various disorders through its anti-inflammatory and antioxidant properties however the effect of MSM on gastric mucosal injury remains unclear. The aim of the present study is to determine whether MSM has beneficial effects on ethanol/HCl-induced gastric ulcer in mice. Macroscopic and histopathological evaluation of gastric mucosa revealed that ethanol/HCl administration produced apparent mucosal injuries, while pretreatment with MSM (200 and 400 mg/kg, orally) could effectively protect gastric mucosa against the injuries caused by acidified ethanol. MSM significantly increased the levels of glutathione (GSH), catalase (CAT) and prostaglandin E2 (PGE2), and decreased the levels of malondialdehyde (MDA), myeloperoxidase (MPO), carbonyl protein, and nitric oxide (NO) in gastric tissues compar ed with those in the ethanol group. MSM suppressed gastric inflammation by reducing the levels of proinflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, monocyte chemoattractant protein (MCP)-1 and matrix metalloproteinase (MMP)-9. Moreover, pretreatment of mice with MSM decreased the expression of nuclear factor kappa B (NF-κB) as a key regulator of inflammation in gastric mucosa. Taken together, these data suggest that MSM is able to decrease the severity of ethanol/HCl-induced gastric mucosal injury through inhibition of oxidative stress and inflammation.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :کیوان امیرشاهرخی
نویسنده :علیرضا خلیلی
Additional Information:Impact Factor (2016) 2.896 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts, BIOSIS,
کلیدواژه ها (انگلیسی):Methylsulfonylmethane; Gastric ulcer; Oxidative stress; Inflammation; Ethanol
Subjects:QV pharmacology
Divisions:School of Pharmacy > Department of Pharmacology
ID Code:9131
Deposited By: Dr Kivan Amir Shahrikhi
Deposited On:23 Jun 1396 07:32
Last Modified:20 May 1399 09:13

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