اثر محافظتی عصاره علف شیر بر آسیب کلیوی و فاکتورهای بیوشیمیایی در موشهای صحرائی دیابتی شده با استرپتوزوسین

ابطحی ایوری, سید حسین and شکوهی, مجید and عباسی, علی and رجب زاده, اصغر and شوره ای, حامد and کلارستاقی, حسین (1396) اثر محافظتی عصاره علف شیر بر آسیب کلیوی و فاکتورهای بیوشیمیایی در موشهای صحرائی دیابتی شده با استرپتوزوسین. Crescent Journal of Medical and Biological Sciences ــ 4 (3). pp. 108-114. شاپا 2148-9696

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Protective Effect of Galega offcinalis Extract on Streptozotocin-Induced Kidney Damage and Biochemical Factor in Diabetic Rats

English Abstract

Objective: Diabetes mellitus (DM) is impairing secretion of insulin or resistance to insulin. Herbal medicine plays an important role in the management of DM. We aimed to test antidiabetic effects of Galega offcinalis on diabetic rats. Materials and Methods: Twenty-eight male Wistar rats were randomly divided into 4 groups (n=7). Diabetes was induced by streptozotocin (STZ) (50 mg/kg). Diabetic rats were calcifed into a diabetic control group (DC), DHEG group (50 mg/ kg hydroalcoholic extract of G. offcinalis), DG group (5 mg/kg glibenclamide). After 20 days, rats’ blood samples, kidney, liver, and pancreas were kept in -70°C to test blood levels of glucose, insulin, lipid profle, some oxidative stress markers and antioxidant enzymes. Results: The fasting blood sugar (FBS) levels in the normal, DHEG, and DG groups were signifcantly lower than the DC group (P<0.05); The levels of insulin in the DC, DHEG, and DG groups were signifcantly lower than the normal group (P<0.05); The serum level of urea and creatinine was signifcantly increased in DC group and signifcantly decreased in other group (P<0.05). Diabetes causes degenerative damages in rats kidney and treatment with G. offcinalis extract protected kidney tissue against diabetes-induced damages. Conclusion: The results of the present study indicated that G. offcinalis could be benefcial for the treatment of diabetes through improving tissue sensitivity to insulin and preventing tissue damages.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سید حسین ابطحی ایوری
نویسنده مسئول :مجید شکوهی
نویسنده :حسین کلارستاقی
Additional Information:Indexed in: ISI(ESCI), Chemical Abstracts, EMBASE, EBSCO, CAB abstracts, DOAJ, Google Scholar, ISC, SID
کلیدواژه ها (انگلیسی):Keywords: Diabetes, Streptozotocin, Galega offcinalis, Kidney damage, Rat
Subjects:QV pharmacology > QV 754 Clinical Pharmacy
QY Clinical Pathology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Anatomy
ID Code:9152
Deposited By: Dr Hossein Kalarestaghy
Deposited On:01 Jul 1396 07:15
Last Modified:27 Nov 1399 07:40

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