قرار گرفتن در معرض استنشاق نانو الماس استرس اکسیداتیو در ریه، قلب و مغز القا می کند.

خسروی, یحیی and سلیمی, احمد and پوراحمد, جلال and ناصر زاده, پروانه and صیدی, عنایت اله (1397) قرار گرفتن در معرض استنشاق نانو الماس استرس اکسیداتیو در ریه، قلب و مغز القا می کند. Xenobiotica ــ 48 (8). pp. 860-866. شاپا 0049-8254

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Official URL: http://www.tandfonline.com/doi/full/10.1080/004982...


Inhalation exposure of nano diamond induced oxidative stress in lung, heart and brain

English Abstract

1. Today, diamond nanoparticles have several industrial applications. Nano diamond (ND) as a carbon allotrope diffuses in the air easily during producing and processing procedures. 2. In this study, we investigated sub-acute exposed to ND at the exposure chamber in mice. The animals were divided into two groups (control and exposed group to ND at the concentration of 3 mg/m3 for 3 h/day, 5 days/week for 30 days) in a whole-body inhalation chamber. 3. Our results showed that exposure to ND induced the hematological and biochemical changes. The target organs for ND were the lungs, brain and heart in the mice, respectively. Also, ND increased reactive oxygen species (ROS) generation, lipid peroxidation (LPO), the collapse of mitochondrial membrane potential (MMP), decreased a level of reduced glutathione (GSH) and finally increased a level of glutathione disulfide (GSSG) in lung, brain and heart tissues. Our results suggest that exposure to ND can induce oxidative stress in the tissue mentioned. 4. These results suggest that exposure of researchers and workers with diamond nanoparticles probably increase a risk of respiratory, cardiovascular and cerebral disorders through oxidative stress. However, good ventilation, appropriate personal protective equipment and using of anti-oxidant compounds in daily diet of worker are suggested.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :یحیی خسروی
نویسنده :احمد سلیمی
نویسنده :جلال پوراحمد
نویسنده مسئول :پروانه ناصر زاده
نویسنده مسئول :عنایت اله صیدی
Additional Information:IF: 1.902 Indexed in: ISI, PubMed/Medline, Scopus, Embase
کلیدواژه ها (انگلیسی):Diamond nanoparticle, occupational exposure, oxidative stress, reactive oxygen spices, sub-acute toxicity
Subjects:QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:9189
Deposited By: Dr Ahmad Salimi
Deposited On:15 Jul 1396 11:17
Last Modified:24 Jan 1401 10:28

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