title

ﻣﻘﺎﻳﺴﻪی ﺗﺎﺛﻴﺮ ﭘﻮﺩﺭ ﺭﻳﺸﻪ ﮔﻴﺎﻩ ﺁﻧﻐﻮﺯﻩ(ﮔﻮﻧﻪOvina) ﻭ ﺍﻣﭙﺮﺍﺯﻭﻝ ﺑﺮ ﺑﻬﺒﻮﺩ ﺯﺧﻢ ﻣﻌﺪﻩ ﻧﺎﺷﻲ ﺍﺯ ﺍﻳﻨﺪﻭﻣﺘﺎﺳﻴﻦ ﺩﺭ ﻣﻮﺵ ﺻﺤﺮﺍﻳﻲ ﻧﺮ

عباسپور چوبی, سید علی اصغر and عابدی, علی and مأذنی, محمد and محمودزاده, یاور and علیپور, محسن (1396) ﻣﻘﺎﻳﺴﻪی ﺗﺎﺛﻴﺮ ﭘﻮﺩﺭ ﺭﻳﺸﻪ ﮔﻴﺎﻩ ﺁﻧﻐﻮﺯﻩ(ﮔﻮﻧﻪOvina) ﻭ ﺍﻣﭙﺮﺍﺯﻭﻝ ﺑﺮ ﺑﻬﺒﻮﺩ ﺯﺧﻢ ﻣﻌﺪﻩ ﻧﺎﺷﻲ ﺍﺯ ﺍﻳﻨﺪﻭﻣﺘﺎﺳﻴﻦ ﺩﺭ ﻣﻮﺵ ﺻﺤﺮﺍﻳﻲ ﻧﺮ. مجله علمی و پژوهشی دانشگاه علوم پزشکی زنجان ــ 25 (110). pp. 24-33. شاپا 1606-9366

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Persian Abstract

ﺯﻣﻴﻨﻪ ﻭ ﻫﺪﻑ: ﮔﻮﻧﻪ ﻫﺎ ﻱ ﻣﺨﺘﻠﻒ ﮔﻴﺎﻩ ﺁﻧﻐﻮﺯﻩ، ﺩﺭ ﻃﺐ ﺳﻨﺘﻲ ﺑﻪ ﻣﻨﻈﻮﺭ ﺩﺭﻣﺎﻥ ﺑﻴﻤﺎﺭ ﻱ ﻫﺎ ﻱ ﻣﺨﺘﻠﻒ ﺑﻪ ﮐﺎﺭ ﺭﻓﺘﻪ، ﺍﺳﺖ ﺍﻣﺎ ﺍﺛﺮﺍﺕ ﺩﺭﻣـﺎﻧﻲ ﺁﻥ ﺑـﺮ ﺯﺧـﻢ ﻣﻌﺪﻩ ﺑﻪ ﺻﻮﺭﺕ ﻋﻠﻤﻲ ﻣﻮﺭﺩ ﻣﻄﺎﻟﻌﻪ ﻗﺮﺍﺭ ﻧﮕﺮﻓﺘﻪ ﺍﺳﺖ . ﺩﺭﺍﻳﻦ ﻣﻄﺎﻟﻌﻪ ﺗﺎﺛﻴﺮ ﺩﺭﻣﺎﻧﻲ ﭘﻮﺩﺭ ﺭﻳﺸﻪ ﮔﻴﺎﻩ ﺁﻧﻐﻮﺯﻩ ﺩﺭ ﺑﻬﺒﻮﺩ ﺯﺧﻢ ﻣﻌﺪﻩ ﻧﺎﺷﻲ ﺍﺯ ﺍﻳﻨﺪﻭﻣﺘﺎﺳﻴﻦ ﺩﺭ ﻣﻮﺵ ﺻﺤﺮﺍ ﻳﻲ ﻧﺮﻣﻮﺭﺩ ﺍﺭﺯ ﻳﺎﺑﻲ ﻗﺮﺍﺭ ﮔﺮﻓﺖ . ﺭﻭﺵ ﺑﺮﺭﺳﻲ : ﺩﺭ ﺍﻳﻦ ﻣﻄﺎﻟﻌﻪ ۵۶ ﺳﺮ ﺭﺕ ﻧﺮ ( ۲۸۰تا ۳۲۰ ﮔﺮﻡ ) ﺩﺭ 4 ﮔﺮﻭﻩ ﺩﺭﻣﺎﻧﻲ ﻭ ۳ ﮔﺮﻭﻩ ﮐﻨﺘﺮﻝ ﺗﻘﺴﻴﻢ ﺷﺪﻧﺪ . ۷۲ ﺳﺎﻋﺖ ﺑﻌـﺪ ﺍﺯ ﻧﺎﺷـﺘﺎ ﻳﻲ ﺑـﻪ همه گروه ها به جز کنترل نرمال ﺍﻳﻨﺪﻭﻣﺘﺎﺳﻴﻦ ( 30 میلی گرم بر کیلوگرم) ﮔﺎﻭﺍﮊ ﮔﺮﺩﻳﺪ. ۵ ﺳﺎﻋﺖ ﺑﻌﺪ ﺳﻮﺳﭙﺎﻧﺴﻮﻥ ﭘﻮﺩﺭ ﺭﻳﺸﻪ ﯼ ﺁﻧﻐـﻮﺯﻩ ﺩﺭ 4 ﺩﻭﺯ ( ۱۰۰۰ ،۵۰۰ ،۲۵۰، ۱۲۵ ﻣﻴﻠﻲ ﮔﺮﻡ ﺑﺮ ﮐﻴﻠﻮﮔﺮﻡ) ﻭ ﺩﺭ ﮔﺮﻭﻩ ﮐﻨﺘﺮﻝ ﻣﺜﺒﺖ ﺳﻮﺳﭙﺎﻧﺴﻴﻮﻥ ﺍﻣﭙﺮﺍﺯﻭﻝ (۲۰ ﻣﻴﻠﻲ ﮔﺮﻡ ﺑﺮ ﮐﻴﻠﻮﮔﺮﻡ) ، ﺩﺭ ﮔـﺮﻭﻩ ﻛﻨﺘـﺮﻝ ﻧﺮﻣﺎﻝ ﻣﻘﺪﺍﺭ ﺑﺮﺍﺑﺮ ﺁﺏ ﻣﻘﻄﺮ ﺑﻪ ﺻﻮﺭﺕ ﺩﻫﺎﻧﻲ ﺩﻭﺑﺎﺭ ﺩﺭ ﺭﻭﺯ ﺑﻪ ﻣﺪﺕ 14 ﺭﻭﺯ ﮔﺎﻭﺍﮊ ﺷﺪ ﻭ ﺩﺭ ﮐﻨﺘﺮﻝ ﻣﻨﻔﻲ ﻫﻴﭻ ﻣﺪﺍﺧﻠﻪ ﺩﺭﻣﺎﻧﻲ ﺻﻮﺭﺕ ﻧﮕﺮﻓﺖ . ﭘـﺲ ﺍﺯ ﭘﺎﻳﺎﻥ ﺩﻭﺭﻩ ﮐﻠﻴﻪ ﯼ ﺣﻴﻮﺍﻧﺎﺕ ﮐﺸﺘﻪ ﻭ ﻣﻌﺪﻩ ﺍﺯ ﻧﻈﺮ ﺯﺧﻢ ﺑﻪ ﺻﻮﺭﺕ ﻣﻴﮑﺮﻭﺳﮑﭙﻲ ﻭ ﻣﺎﮐﺮﻭﺳﮑﭙﻲ ﻣﻮﺭﺩ ﺍﺭﺯﻳﺎﺑﻲ ﻗﺮﺍﺭ ﮔﺮﻓﺘﻨﺪ . ﻳﺎﻓﺘﻪ ﻫﺎ : ﺩﻭﺯﻫﺎ ﻱ ﻣﺨﺘﻠﻒ ﭘﻮﺩﺭ ﺭﻳﺸﻪ ﺁﻧﻐﻮﺯﻩ ﺗﺎﺛﻴﺮ ﺩﺭﻣﺎﻧﻲ ﻣﻄﻠﻮﺑﻲ ﺑﻪ ﺧﺼﻮﺹ ﺩﺭ ﺩﻭﺯﻫﺎ ﻱ ۲۵۰،۵۰۰ و 1000 ﺑﺮ ﺯﺧﻢ ﻣﻌﺪﻩ ﺩﺍﺷﺘﻨﺪ( ۱۰۰ ﺩﺭﺻـﺪ) و ﻓﻘﻂ ﺩﺭ ﺩﻭﺯ33/ ۳۳ ﺩﺭصد ﺍﺯ ﺭﺕ ﻫﺎ ﺯﺧﻢ ﻫﻤﭽﻨﺎﻥ ﻗﺎﺑﻞ ﻣﺸﺎﻫﺪﻩ ﺑﻮﺩ . ﺩﺭ ﮔﺮﻭﻩ ﮐﻨﺘﺮﻝ ﻣﻨﻔﻲ ، ﻫﻴﭻ ﺑﻬﺒﻮﺩﻱ ﺩﺭ ﺯﺧﻢ ﻫﺎ ﻣﺸﺎﻫﺪﻩ ﻧﺸﺪ ﻭ ﻫﻤـﻪ ﯼ ﺣﻴﻮﺍﻧﺎﺕ ﺩﺭ ﺭﻭﺯﻫﺎ ﻱ ﺍﻭﻟﻴﻪ ﺍﺯ ﺑﻴﻦ ﺭﻓﺘﻨﺪ . ﺩﺭ ﮔﺮﻭﻩ ﺩﺭﻳﺎﻓﺖ ﮐﻨﻨﺪﻩ ﯼ ﺍﻣﭙﺮﺍﺯﻭﻝ ﺩﺭ ۴۰ ﺩﺭﺻﺪ ﺍﺯ ﺭﺕ ﻫﺎ ﺯﺧﻢ ﻗﺎﺑﻞ ﻣﺸﺎﻫﺪﻩ ﺑﻮﺩ . ﺑﺮﺭﺳﻲ ﺁ ﻣﺎﺭﻱ ﺩﻭ ﺑـﻪ ﺩﻭ ﺑﻪ ﻣﻨﻈﻮﺭ ﻣﻘﺎﻳﺴﻪ ﮔﺮﻭﻩ ﻫﺎ ﻱ ﺩﺭﻣﺎﻧﻲ ﺗﻔﺎﻭﺕ ﺁﻣﺎﺭﻱ ﻣﻌﻨﻲ ﺩﺍﺭﻱ ﺭﺍ ﺑﺎ ﮔﺮﻭﻩ ﺍﻣﭙﺮﺍﺯﻭﻝ ﻧﺸﺎﻥ ﺩﺍﺩ . ﻧﺘﻴﺠﻪ ﮔﻴﺮﻱ :ﻧﺘﺎﻳﺞ ﺍﻳﻦ ﻣﻄﺎﻟﻌﻪ ﭘﻴﺸﻨﻬﺎﺩ ﻣﻲ ﮐﻨﻨﺪ ﮐﻪ ﺍﺳﺘﻔﺎﺩﻩ ﺍﺯ ﭘﻮﺩﺭ ﺭ ﻳﺸﻪ ﺁﻧﻐﻮﺯﻩ ﺩﺭ ﻣﻘﺎﻳﺴﻪ ﺑﺎ ﺍﻣﭙﺮﺍﺯﻭﻝ ﺗﺎﺛﻴﺮ ﺑﻬﺘـﺮﻱ ﺑـﺮ ﺑﻬﺒـﻮ ﺩ ﺯﺧـﻢ ﻣﻌـﺪﻩ ﻧﺎﺷـﻲ ﺍﺯ ﺍﻳﻨﺪﻭﻣﺘﺎﺳﻴﻦ ﺩﺍﺭﺩ .

Title

Comparative Effects of Root Powder of Ferula (Ovina) and Omeperazole for Treatment of Indomethacin-Induced Gastric Ulcer in Male Rat

English Abstract

Background and Objective: Although Ferula spices have been used in traditional medicine, their therapeutic effects on gastric ulcers have not yet been proven in modern medicine. In this study we examined the healing effects of the root powder of Ferula Ovina against indomethacin-induced gastric ulcers in male rats. aterials and Method: In this experimental study 56 male rats (280-320gr) were randomly divided into four treatment groups (n=8) and three control groups. 72 hours after fasting, indomethacin (30mg/kg) was administered through gavage in all groups (except in normal control). After 5 hours, the root powder suspension was administered in four doses (125, 250, 500, 1000mg/kg) while in the positive control groups omeprazole (20mg/kg) was administered orally and in the normal control group equal distilled water was administered two times per day for two weeks. In the negative control group, treatment intervention was not performed. After completion of treatment period (two weeks), the animals were killed and stomach ulcers were examined both macroscopically and microscopically. Results: All different concentrations of Ferula root powder suspension were effective in treating gastric ulcers especially 250, 500 and 1000 mg/kg doses which proved to be the most effective (100%). In the 125 mg/kg dose, stomach ulcers were observed in 2 out of 6 mice (33.33%). In the omeprazole group, ulcer healing was observed in 2 of 5 rats (40%). All animals in the negative control group expired without any effect on gastric ulcers. Statistical analysis showed a significant difference between the treatment groups and the omeprazole group. Conclusion: Our results suggest that root powder of Ferula Ovina is more effective in healing indomethacin -induced ulcers in comparison to omeprazole.

Item Type:Article
زبان سند : فارسی
نویسنده اول :سید علی اصغر عباسپور چوبی
نویسنده :علی عابدی
نویسنده :محمد مأذنی
نویسنده مسئول :محسن علیپور
Additional Information:Indexed in: Scopus, EBSCO, EMRO, Google Scholar, SID, SIC, Magiran, Barakatkns
Uncontrolled Keywords:ﺯﺧﻢ ﻣﻌﺪﻩ، ﮔﻴﺎﻩ ﺁﻧﻐﻮﺯﻩ، ﺍﻳﻨﺪﻭﻣﺘﺎﺳﻴﻦ ، ﺍﻣﭙﺮﺍﺯﻭﻝ
کلیدواژه ها (انگلیسی):Peptic ulcer, Ferula, Indomethacin, Omeprazole
Subjects:QU Biochemistry
QV pharmacology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
ID Code:9220
Deposited By: Dr Mohammad Mazani
Deposited On:24 Jul 1396 06:03
Last Modified:24 Jul 1396 06:03

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