title

کورکومین از میتوکندری ها و کاردیومیسیت ها در مقابل آسیب اکسیداتیو وآپوپتوز القاء شده توسط سم Hemiscorpius Lepturus محافظت میکند.

ناصر زاده, پروانه and نکوهی مهر, سارا and سعدآبادی, زینب and صیدی, عنایت اله and سلیمی, احمد and پوراحمد, جلال (1396) کورکومین از میتوکندری ها و کاردیومیسیت ها در مقابل آسیب اکسیداتیو وآپوپتوز القاء شده توسط سم Hemiscorpius Lepturus محافظت میکند. Drug Research ــ online . شاپا 2194-9379

[img] Text
محدود به Repository staff only

736kB

Official URL: https://www.ncbi.nlm.nih.gov/pubmed/?term=Curcumin...


Title

Curcumin Protects Mitochondria and Cardiomyocytes from Oxidative Damage and Apoptosis Induced by Hemiscorpius Lepturus Venom

English Abstract

The main aim of the current study was to determine cardiotoxicity mechanisms of H. lepturus and protective effect of curcumin against this toxin in rats, using isolated heart mitochondria and cardiomyocytes. Our findings indicated that H. lepturus venom caused significantly ((P < 0.05) cytotoxicity and caspase 3 activation in cardiomyocytes and mitochondrial dysfunction including increased mitochondrial ROS level, swelling in the mitochondria, decline in the mitochondria membrane potential (MMP), decrease in the cytochrome-c oxidase activity (complex IV), decrease ATP level and finally mitochondrial outer membrane (MOM) rupture in isolated mitochondria. Our results showed that the administration of curcumin efficiently decreased (P< 0.05) cytotoxicity and caspase 3 activation, ROS formation, MMP collapse, mitochondrial swelling and mitochondrial outer membrane (MOM) rupture. Our findings suggest H. lepturus venom cusses a disruptive effect on mitochondrial respiratory chain, especially on complex II, and IV that predispose cardiomyocytes to ATP depletion and death signaling that could be protected with administration of curcumin.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :پروانه ناصر زاده
نویسنده مسئول :احمد سلیمی
نویسنده مسئول :جلال پوراحمد
Additional Information:Indexed in: ESCI, Pubmed/Medline/index Medicus, Scopus, Chemical Abstracts
کلیدواژه ها (انگلیسی):hemiscorpius lepturus, isolated mitochondria, heart, curcumin
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:9225
Deposited By: دکتر احمد سلیمی
Deposited On:22 Aug 1396 09:46
Last Modified:22 Aug 1396 09:46

Repository Staff Only: item control page

Document Downloads

More statistics for this item...