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اوزون/اکسیژن درمانی ملایم آنتی اکسیدان های آنزیمی و غیره آنزیمی را افزایش می دهد که از کاهش شنوایی ناشی از صوت محافظت میکند.

ناصر زاده, پروانه and شاهی, فرشاد and فریدونی, محمد جواد and صیدی, عنایت اله and ایزدی, مرتضی and سلیمی, احمد (1396) اوزون/اکسیژن درمانی ملایم آنتی اکسیدان های آنزیمی و غیره آنزیمی را افزایش می دهد که از کاهش شنوایی ناشی از صوت محافظت میکند. Free Radical Research ــ 51 (9-10). pp. 828-837. شاپا 1071-5762

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Official URL: http://www.tandfonline.com/doi/full/10.1080/107157...


Title

Moderate O-3/O-2 therapy enhances enzymatic and non-enzymatic antioxidant in brain and cochlear that protects noise-induced hearing loss

English Abstract

Mitochondrial damage and oxidative stress are known to contribute to the pathogenesis of noise-induced hearing loss (NIHL). In this study, we examined the protective effect of O2/O3 mixture (ozone/oxygen) therapy against mitochondrial induced damage and oxidative stress by noise exposure in rat brain and cochlear. For this purpose, rats were divided into four groups: 1–control group; 2–noise exposed group (100 dB); 3–noise O2/O3, and4–O2/O3 (30 mg/ml). After 14 d, animals were anesthetised. Rat brain and cochlear tissue were removed for evaluation of the histopathological damages, oxidative stress, and mitochondrial dysfunction in both tissues. Our findings indicated that noise caused pathological damage, oxidative stress, and mitochondrial dysfunction in rat brain and cochlear. Also, daily administration of an O2/O3 therapy (30 mg/ml intravenous) efficiently increased enzymatic and non-enzymatic antioxidant in brain and cochlear that this action led to inhibition of pathological damages, oxidative stress, reactive oxygen species formation, mitochondrial membrane potential (MMP) collapse, mitochondrial swelling, and cytochrome c release resulting from noise. These findings suggest that the moderate O2/O3 therapy enhances the capacity of enzymatic and non-enzymatic antioxidant in brain and cochlear that protects against NIHL.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :پروانه ناصر زاده
نویسنده :فرشاد شاهی
نویسنده :محمد جواد فریدونی
نویسنده :عنایت اله صیدی
نویسنده مسئول :مرتضی ایزدی
نویسنده مسئول :احمد سلیمی
Additional Information:IF: 3.038 Indexed in: ISI, PubMed/Medline, Scopus, Embase
کلیدواژه ها (انگلیسی):Ozone/oxygen therapy; oxidative stress; mitochondria; noise; hearing loss
Subjects:QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:9227
Deposited By: Dr Ahmad Salimi
Deposited On:29 Jul 1396 12:01
Last Modified:24 Jan 1401 10:23

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