همبستگی پروتئین و چسبندگی عروق سرم 1 با محدودیت جریان هوا و کیفیت زندگی در بیماری انسداد مزمن ریوی

Title

Correlation of serum vascular adhesion protein-1 with airflow limitation and quality of life in stable chronic obstructive pulmonary disease

English Abstract

tObjective: The serum vascular adhesion protein-1 (VAP-1) level increases in chronic inflammatory diseases. The present study aimed to examine serum VAP-1 level in patients with stable chronic obstructive pulmonary disease (COPD) and the correlation of this marker with airflow limitation and health-related quality of life using the {COPD} Assessment Test (CAT). Materials and methods We measured serum VAP-1 level in 43 patients with stable {COPD} and 30 control subjects and compared them with airflow limitation according to the {COPD} stage in the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) criteria, peripheral {O2} saturation (SpO2), and {CAT} score. We also tested the association of serum VAP-1 level with {COPD} patients' clinical parameters. Results Serum VAP-1 level increased with increasing severity of {COPD} according to the {GOLD} classification (P = 0.007). It also increased in patients with high {CAT} groups and high values on the modified Medical Research Council dyspnea scale (P = 0.012 and P = 0.015, respectively). In addition, there was a significant positive correlation between serum VAP-1 level and both SpO2 and {CAT} score (r = �0.404, P = 0.007; r = 0.482, P = 0.001, respectively). Conclusion The study showed that serum VAP-1 level increased with an increasing severity of obstruction in patients with stable COPD. This increase was associated with a reduced quality of life and increased severity of hypoxia. These results suggest that inhibiting serum VAP-1 level in {COPD} patients may be useful in managing the disease.

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