امانی, مجتبی and قدیمی, نعیمه and اصلانی, محمدرضا and قبادی مراللو, حسن (1396) همبستگی پروتئین و چسبندگی عروق سرم 1 با محدودیت جریان هوا و کیفیت زندگی در بیماری انسداد مزمن ریوی. Respiratory Medicine ــ online . شاپا 0954-6111
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Title
Correlation of serum vascular adhesion protein-1 with airflow limitation and quality of life in stable chronic obstructive pulmonary disease
English Abstract
tObjective: The serum vascular adhesion protein-1 (VAP-1) level increases in chronic inflammatory diseases. The present study aimed to examine serum VAP-1 level in patients with stable chronic obstructive pulmonary disease (COPD) and the correlation of this marker with airflow limitation and health-related quality of life using the {COPD} Assessment Test (CAT). Materials and methods We measured serum VAP-1 level in 43 patients with stable {COPD} and 30 control subjects and compared them with airflow limitation according to the {COPD} stage in the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) criteria, peripheral {O2} saturation (SpO2), and {CAT} score. We also tested the association of serum VAP-1 level with {COPD} patients' clinical parameters. Results Serum VAP-1 level increased with increasing severity of {COPD} according to the {GOLD} classification (P = 0.007). It also increased in patients with high {CAT} groups and high values on the modified Medical Research Council dyspnea scale (P = 0.012 and P = 0.015, respectively). In addition, there was a significant positive correlation between serum VAP-1 level and both SpO2 and {CAT} score (r = �0.404, P = 0.007; r = 0.482, P = 0.001, respectively). Conclusion The study showed that serum VAP-1 level increased with an increasing severity of obstruction in patients with stable COPD. This increase was associated with a reduced quality of life and increased severity of hypoxia. These results suggest that inhibiting serum VAP-1 level in {COPD} patients may be useful in managing the disease.
Item Type: | Article |
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زبان سند : | انگلیسی |
نویسنده اول : | مجتبی امانی |
نویسنده : | نعیمه قدیمی |
نویسنده : | محمدرضا اصلانی |
نویسنده مسئول : | حسن قبادی مراللو |
Additional Information: | Impact Factor(2016) 3.217 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, AIDS Abstracts, Current Contents/Life Sciences and Clinical Medicine, EMBASE, Excerpta Medica, Current Awareness in Biological Sciences, SIIC Data Bases |
کلیدواژه ها (انگلیسی): | Chronic obstructive pulmonary disease; Serum VAP-1; CAT score; mMRC |
Subjects: | QU Biochemistry WX Hospital and other health Facilities |
Divisions: | Faculty of Medicine > Department of Basic Sciences > Department of Biophysics |
ID Code: | 9272 |
Deposited By: | Dr Mojtaba Amani |
Deposited On: | 30 Jul 1396 11:19 |
Last Modified: | 11 Aug 1396 08:57 |
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