همبستگی پروتئین و چسبندگی عروق سرم 1 با محدودیت جریان هوا و کیفیت زندگی در بیماری انسداد مزمن ریوی

امانی, مجتبی and قدیمی, نعیمه and اصلانی, محمدرضا and قبادی مراللو, حسن (1396) همبستگی پروتئین و چسبندگی عروق سرم 1 با محدودیت جریان هوا و کیفیت زندگی در بیماری انسداد مزمن ریوی. Respiratory Medicine ــ online . شاپا 0954-6111

[img] Text
محدود به Repository staff only


Official URL: http://www.sciencedirect.com/science/article/pii/S...


Correlation of serum vascular adhesion protein-1 with airflow limitation and quality of life in stable chronic obstructive pulmonary disease

English Abstract

tObjective: The serum vascular adhesion protein-1 (VAP-1) level increases in chronic inflammatory diseases. The present study aimed to examine serum VAP-1 level in patients with stable chronic obstructive pulmonary disease (COPD) and the correlation of this marker with airflow limitation and health-related quality of life using the {COPD} Assessment Test (CAT). Materials and methods We measured serum VAP-1 level in 43 patients with stable {COPD} and 30 control subjects and compared them with airflow limitation according to the {COPD} stage in the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) criteria, peripheral {O2} saturation (SpO2), and {CAT} score. We also tested the association of serum VAP-1 level with {COPD} patients' clinical parameters. Results Serum VAP-1 level increased with increasing severity of {COPD} according to the {GOLD} classification (P = 0.007). It also increased in patients with high {CAT} groups and high values on the modified Medical Research Council dyspnea scale (P = 0.012 and P = 0.015, respectively). In addition, there was a significant positive correlation between serum VAP-1 level and both SpO2 and {CAT} score (r = �0.404, P = 0.007; r = 0.482, P = 0.001, respectively). Conclusion The study showed that serum VAP-1 level increased with an increasing severity of obstruction in patients with stable COPD. This increase was associated with a reduced quality of life and increased severity of hypoxia. These results suggest that inhibiting serum VAP-1 level in {COPD} patients may be useful in managing the disease.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :مجتبی امانی
نویسنده :نعیمه قدیمی
نویسنده :محمدرضا اصلانی
نویسنده مسئول :حسن قبادی مراللو
Additional Information:Impact Factor(2016) 3.217 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, AIDS Abstracts, Current Contents/Life Sciences and Clinical Medicine, EMBASE, Excerpta Medica, Current Awareness in Biological Sciences, SIIC Data Bases
کلیدواژه ها (انگلیسی):Chronic obstructive pulmonary disease; Serum VAP-1; CAT score; mMRC
Subjects:QU Biochemistry
WX Hospital and other health Facilities
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biophysics
ID Code:9272
Deposited By: Dr Mojtaba Amani
Deposited On:30 Jul 1396 11:19
Last Modified:11 Aug 1396 08:57

Repository Staff Only: item control page

Document Downloads

More statistics for this item...