رضایی مقدم, عادل and پات راد, الهام and تفسیری, الهام and Peng, Warner and Fangman, Benjamin and Pluard, Timothy J and Accurso, Anthony and Salacz, Michael and Shah, Kushal and Ricke, Brandon and Bi, Danse and Kimura, Kyle and Graves, Leland and خواجویی نژاد, مرضیه and دولتخواه, رویا and صنعت, زهره and یزدی, مینا and توکلی نیا, نعیمه and مأذنی, محمد and امانی, مجتبی and قوامی, سعید and Gartell, Robyn and Reilly, Colleen and Naima, Zaid and اسفندیاری, طوبی and Farassati, Faris (1396) مسیر پیام رسانی Ral در سلامتی و سرطان. Cancer Medicine ــ online . pp. 1-3. شاپا 2045-7634
|
Text
383kB |
Official URL: http://onlinelibrary.wiley.com/doi/10.1002/cam4.11...
Title
Ral signaling pathway in health and cancer
English Abstract
The Ral (Ras-Like) signaling pathway plays an important role in the biology of cells. A plethora of effects is regulated by this signaling pathway and its prooncogenic effectors. Our team has demonstrated the overactivation of the RalA signaling pathway in a number of human malignancies including cancers of the liver, ovary, lung, brain, and malignant peripheral nerve sheath tumors. Additionally, we have shown that the activation of RalA in cancer stem cells is higher in comparison with differentiated cancer cells. In this article, we review the role of Ral signaling in health and disease with a focus on the role of this multifunctional protein in the generation of therapies for cancer. An improved understanding of this pathway can lead to development of a novel class of anticancer therapies that functions on the basis of intervention with RalA or its downstream effectors.
| Item Type: | Article |
|---|---|
| زبان سند : | انگلیسی |
| نویسنده اول : | عادل رضایی مقدم |
| نویسنده : | محمد مأذنی |
| نویسنده : | مجتبی امانی |
| نویسنده مسئول : | Faris Farassati |
| Additional Information: | Impact factor (2016) 3.362 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts Service, |
| کلیدواژه ها (انگلیسی): | Aurora Kinase, biology, cancer, cancer stem cells, Ral, therapy |
| Subjects: | QU Biochemistry |
| Divisions: | Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry School of Pharmacy > Department Biophysical |
| ID Code: | 9274 |
| Deposited By: | Dr Mojtaba Amani |
| Deposited On: | 02 Aug 1396 10:14 |
| Last Modified: | 20 May 1399 08:33 |
Repository Staff Only: item control page