آیا هلیکو باکتر پیلوری ژنوتیپ شدیدا سیتو توکسیک با ادنو کارسینوم کاردی مرتبط است؟

بختی, سیده زهرا ، لطیفی نوید, سعید ، زهری, صابر ، بختی, فاطمه سادات ، حاجوی, ناصر ، یزدانبد, عباس (1396) آیا هلیکو باکتر پیلوری ژنوتیپ شدیدا سیتو توکسیک با ادنو کارسینوم کاردی مرتبط است؟. Cancer biomarker ــ Online . شاپا 1574-0153

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عنوان انگليسي

Are Helicobacter pylori highly cytotoxic genotypes and cardia gastric adenocarcinoma linked? Lessons from Iran

خلاصه انگلیسی

Abstract: BACKGROUND: Although the most extensive studies revealed the role of H. pylori VacA and CagA toxins in the development of gastric adenocarcinoma, the magnitude of this association and the correlations of vacA mosaicism and cagA status with cardia gastric adenocarcinoma (CGA) still remain controversial. OBJECTIVE: We aimed to examine the linkage of H. pylori highly cytotoxic genotypes to CGA in Iranian populations as a model. METHODS: A total of 601 Iranian patients were enrolled. Biopsies were cultured, genotyped, and anatomically and histologically classified. RESULTS: The vacA c1 genotype, but not cagA status, showed a strong association with the risk of both CGA and non-cardia adenocarcinoma (NCGA), whether the controls were non-tumors, as those with either non-atrophic gastritis or peptic ulcerations, (the OR (95%CI) was 14.11 (4.91–40.52) and 9.59 (4.06–22.65), respectively) or those with NAG (the OR (95%CI) was 10.71 (3.49–32.82) and 8.11 (3.26–20.16), respectively). The vacA c1/cagA+ genotype was significantly associated with an increased risk of NCGA, whether the controls were non-tumors or those with NAG; the adjusted risk was 4.706 (1.41–15.67) and 4.85 (1.42–16.51), respectively. CONCLUSIONS: The H. pylori vacA c1 genotype, but not cagA status, might be the first important bacterial biomarker for predicting the cardia adenocarcinoma risk in male patients aged ⩾ 55 in Iran.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :سیده زهرا بختی
نویسنده مسئول :سعید لطیفی نوید
نویسنده :فاطمه سادات بختی
نویسنده :ناصر حاجوی
نویسنده :عباس یزدانبد
اطلاعات اضافی :Impact Factor (2016) 2.274 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts Service, Academic Source Complete, CAB Abstracts, EBSCO databases, Elsevier BIOBASE, Embase, EMBIO, Google Scholar,Microsoft Academic Search, Prous Science Integrity, PubsHub, Ulrich's Periodicals Directory, Web of Science: Biological Abstracts, Web of Science: BIOSIS Previews
کلید واژه ها (انگلیسی):Keywords: Helicobacter pylori, vacA c, cagA, cardia gastric adenocarcinoma, diffuse-type gastric adenocarcinoma, intestinal-type gastric adenocarcinoma
موضوعات :WI سیستم گوارشی
بخش های دانشگاهی :دانشكده پزشكي > گروه داخلی ، قلب ، عفونی
کد شناسایی :9305
ارائه شده توسط : دکتر بهمن بشردوست
ارائه شده در تاریخ :08 آبان 1396 08:16
آخرین تغییر :08 آبان 1396 08:16

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