آیا هلیکو باکتر پیلوری ژنوتیپ شدیدا سیتو توکسیک با ادنو کارسینوم کاردی مرتبط است؟

بختی, سیده زهرا and لطیفی نوید, سعید and زهری, صابر and بختی, فاطمه سادات and حاجوی, ناصر and یزدانبد, عباس (1396) آیا هلیکو باکتر پیلوری ژنوتیپ شدیدا سیتو توکسیک با ادنو کارسینوم کاردی مرتبط است؟. Cancer biomarker ــ Online . شاپا 1574-0153


Official URL: https://content.iospress.com/search?q=yazdanbod&pu...


Are Helicobacter pylori highly cytotoxic genotypes and cardia gastric adenocarcinoma linked? Lessons from Iran

English Abstract

Abstract: BACKGROUND: Although the most extensive studies revealed the role of H. pylori VacA and CagA toxins in the development of gastric adenocarcinoma, the magnitude of this association and the correlations of vacA mosaicism and cagA status with cardia gastric adenocarcinoma (CGA) still remain controversial. OBJECTIVE: We aimed to examine the linkage of H. pylori highly cytotoxic genotypes to CGA in Iranian populations as a model. METHODS: A total of 601 Iranian patients were enrolled. Biopsies were cultured, genotyped, and anatomically and histologically classified. RESULTS: The vacA c1 genotype, but not cagA status, showed a strong association with the risk of both CGA and non-cardia adenocarcinoma (NCGA), whether the controls were non-tumors, as those with either non-atrophic gastritis or peptic ulcerations, (the OR (95%CI) was 14.11 (4.91–40.52) and 9.59 (4.06–22.65), respectively) or those with NAG (the OR (95%CI) was 10.71 (3.49–32.82) and 8.11 (3.26–20.16), respectively). The vacA c1/cagA+ genotype was significantly associated with an increased risk of NCGA, whether the controls were non-tumors or those with NAG; the adjusted risk was 4.706 (1.41–15.67) and 4.85 (1.42–16.51), respectively. CONCLUSIONS: The H. pylori vacA c1 genotype, but not cagA status, might be the first important bacterial biomarker for predicting the cardia adenocarcinoma risk in male patients aged ⩾ 55 in Iran.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سیده زهرا بختی
نویسنده مسئول :سعید لطیفی نوید
نویسنده :فاطمه سادات بختی
نویسنده :ناصر حاجوی
نویسنده :عباس یزدانبد
Additional Information:Impact Factor (2016) 2.274 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts Service, Academic Source Complete, CAB Abstracts, EBSCO databases, Elsevier BIOBASE, Embase, EMBIO, Google Scholar,Microsoft Academic Search, Prous Science Integrity, PubsHub, Ulrich's Periodicals Directory, Web of Science: Biological Abstracts, Web of Science: BIOSIS Previews
کلیدواژه ها (انگلیسی):Keywords: Helicobacter pylori, vacA c, cagA, cardia gastric adenocarcinoma, diffuse-type gastric adenocarcinoma, intestinal-type gastric adenocarcinoma
Subjects:WI Digestive System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:9305
Deposited By: Dr Bahman Bashardoust
Deposited On:08 Aug 1396 08:16
Last Modified:08 Aug 1396 08:16

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