بررسی ارتباط پلی مورفیسم ژن CCR6(rs1854853) در بیماران ایرانی مبتلا به بیماری آرتریت روماتوئید

Title

Association study of CCR6 gene single nucleotide polymorphism with susceptibility to rheumatoid arthritis in Iranian population

English Abstract

Abstract Background: Several genome-wide association studies (GWAS) have identified numerous susceptibility genes for risk of rheumatoid arthritis (RA). Besides, a bulk of individual association studies in various population has disclosed that genetics is significantly responsible for RA pathogenesis. CCR6 is a chemokine, which is involved in the infiltration of inflammatory cells to sites of immune response. In this study, the association of CCR6 gene rs1854853 single nucleotide polymorphism (SNP) with susceptibility to RA was evaluated in Iranian population. Methods: The investigated population was comprised of 250 RA patients and 500 healthy individuals. Real time TaqMan MGB-based PCR allelic discrimination approach was employed to genotype the samples with regard to CCR6 gene rs1854853 SNP. Results: Considering the A allele of rs1854853 SNP as reference, the G allele did not demonstrate different prevalence between RA patients and controls (P= 0.17). Moreover, AG and GG genotypes were almost equally distributed between cases and control (P= 0.61 and 0.14, respectively). Alternately, the dominant model of AG+GG had no significant difference of frequency between study groups (P= 0.36). Moreover, genotypes did show correlation with clinical data of RA patients. Conclusions: Results suggest that CCR6 gene rs1854853 SNP is not involved in genetic pathogenesis of RA in Iranian population.

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