قبادی مراللو, حسن and اصلانی, محمدرضا and حسینیان, عدالت and فرزانه, اسماعیل (1396) ارتباط سطح سرمی پپتید ناتریوارتیک مغزی و اینترلوکین 6 با کیفیت زندگی در بیماران COPD. Medical Principles and Practice ــ online . pp. 1-21. شاپا 1011-7571
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Official URL: https://www.karger.com/Article/Abstract/484900
Title
The Correlation of Serum Brain Natriuretic Peptide and Interleukin-6 with Quality of Life Using Chronic Obstructive Pulmonary Disease Assessment Test
English Abstract
Objective: The aim of this study was to determine the levels of serum pro-brain natriuretic peptide (pro-BNP) and interleukin (IL)-6 in patients with stable chronic obstructive pulmonary disease (COPD) and to correlate these markers with health-related quality of life using COPD assessment test (CAT). Materials and Method: Serum pro-BNP and IL-6 levels were measured in 82 patients with stable COPD. Serum pro-BNP and serum IL-6 levels, pulmonary function, and oxygen saturation (Spo2) were measured according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage and CAT score. Also, the associations of both pro-BNP and IL-6 with clinical parameters of patients were tested. Results: The serum levels of IL-6 (7.57 (5-11.16) pg/ml) and pro- BNP (120.55 (92.89-144.20) pg/ml) were higher with enhancing disease severity based on the GOLD classification (p=0.034 and p=0.068, respectively). Also, that serum levels of pro-BNP (120.55 (89.50-147.90) pg/ml) and IL-6 (6.68 (4.40-11.97) pg/ml) were increased in patients with high CAT scores (p=0.004 and p=0.017, respectively). There was a significant positive correlation between plasma pro-BNP and IL-6 levels (r= 0.332, p=0.002). Conclusion: The results demonstrated that with increased severity of obstruction based on the GOLD criteria both IL-6 and pro-BNP were elevated. This increase in inflammatory markers was associated with reduced quality of life and severity of hypoxia. These findings indicated that lowering IL-6 and pro-BNP could be useful in the management of COPD patients.
Item Type: | Article |
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زبان سند : | انگلیسی |
نویسنده اول : | حسن قبادی مراللو |
نویسنده مسئول : | محمدرضا اصلانی |
نویسنده : | عدالت حسینیان |
نویسنده : | اسماعیل فرزانه |
Additional Information: | Impact Factor (2016) 1.469 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Google Scholar, Embase, Pathway Studio, EMCare, Academic Search, CINAHL Complete , STM Source , WorldCat |
کلیدواژه ها (انگلیسی): | Chronic Obstructive Pulmonary Disease, pro-BNP, IL-6, CAT |
Subjects: | QT physiology WF Respiratory System |
Divisions: | Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious Faculty of Medicine > Department of Basic Sciences > Department of physiology |
ID Code: | 9424 |
Deposited By: | Dr Mohammad Reza Aslani |
Deposited On: | 11 Sep 1396 06:17 |
Last Modified: | 11 Apr 1399 11:44 |
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