ارتباط سطح سرمی پپتید ناتریوارتیک مغزی و اینترلوکین 6 با کیفیت زندگی در بیماران COPD

قبادی مراللو, حسن and اصلانی, محمدرضا and حسینیان, عدالت and فرزانه, اسماعیل (1396) ارتباط سطح سرمی پپتید ناتریوارتیک مغزی و اینترلوکین 6 با کیفیت زندگی در بیماران COPD. Medical Principles and Practice ــ 26 (6). pp. 509-515. شاپا 1011-7571

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Official URL: https://www.karger.com/Article/Abstract/484900


The Correlation of Serum Brain Natriuretic Peptide and Interleukin-6 with Quality of Life Using Chronic Obstructive Pulmonary Disease Assessment Test

English Abstract

Objective: The aim of this study was to determine the levels of serum pro-brain natriuretic peptide (pro-BNP) and interleukin (IL)-6 in patients with stable chronic obstructive pulmonary disease (COPD) and to correlate these markers with health-related quality of life using COPD assessment test (CAT). Materials and Method: Serum pro-BNP and IL-6 levels were measured in 82 patients with stable COPD. Serum pro-BNP and serum IL-6 levels, pulmonary function, and oxygen saturation (Spo2) were measured according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage and CAT score. Also, the associations of both pro-BNP and IL-6 with clinical parameters of patients were tested. Results: The serum levels of IL-6 (7.57 (5-11.16) pg/ml) and pro- BNP (120.55 (92.89-144.20) pg/ml) were higher with enhancing disease severity based on the GOLD classification (p=0.034 and p=0.068, respectively). Also, that serum levels of pro-BNP (120.55 (89.50-147.90) pg/ml) and IL-6 (6.68 (4.40-11.97) pg/ml) were increased in patients with high CAT scores (p=0.004 and p=0.017, respectively). There was a significant positive correlation between plasma pro-BNP and IL-6 levels (r= 0.332, p=0.002). Conclusion: The results demonstrated that with increased severity of obstruction based on the GOLD criteria both IL-6 and pro-BNP were elevated. This increase in inflammatory markers was associated with reduced quality of life and severity of hypoxia. These findings indicated that lowering IL-6 and pro-BNP could be useful in the management of COPD patients.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :حسن قبادی مراللو
نویسنده مسئول :محمدرضا اصلانی
نویسنده :عدالت حسینیان
نویسنده :اسماعیل فرزانه
Additional Information:IF:1.469 Indexed in: ISI, PubMed/Medline, Scopus, Embase
کلیدواژه ها (انگلیسی):Chronic Obstructive Pulmonary Disease, pro-BNP, IL-6, CAT
Subjects:QT physiology
WF Respiratory System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:9424
Deposited By: Dr Mohammad Reza Aslani
Deposited On:11 Sep 1396 06:17
Last Modified:26 Jun 1402 13:21

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