مقایسه‏ اثرات افزودن میدازولام به بوپیواکایین در بی‏حسی اسپاینال

Title

The effects of adding intrathecal midazolam to bupivacaine in spinal anesthesia

English Abstract

Aim:To study of intrathecal bupivacaine with and without midazolam to assess its effect on the onset, duration of sensory and motor block in lower limb surgery. Materials and methods: Eighty patients were randomly allocated to two groups: 40 patients in the control group received 3 ml of 0.5% bupivacaine plus 0.4 ml of 0.9% saline intrathecally; 40 patients in the midazolam group received 3ml of 0.5% bupivacaine plus 0.4 ml (2mg) midazolam. The onset, duration of sensory/motor block, side effects, sedation score and time for request for first rescue analgesia were noted in two groups. Data collected by questionnaires and the data were extracted and analyzed by SPSS software with Ch-square and T-tests. Results: There was not significantly deference in onset of sensory and motor block between the groups (p>0.05). The duration of sensory and motor block was prolonged in the midazolam group significantly (p-value =0.005, p-value = 0.014 respectively). There were no episodes of hypotension, bradycardia, pruritus, vomiting and urinary retention in any patients. Incidence of nausea and sedation score was comparable in the two group. Sedation score in the Midazolam group (3 patient had grade 1 sedation , 35 patients had grade 2 sedation and 2 patients had grade 3) was slightly higher than control group (1 patient had grade 1 sedation , 32 patients had grade 2 sedation and 7 patients had grade 3) (p=0.05). Request time for first rescue analgesia (Diclofenac) was longer in patients who received midazolam (147.38 versus 215.88, p-value<0.001). Conclusion: Intrathecal midazolam increased the duration of sensory and motor block without increasing side effects.

Document Downloads