title

کوانتوم دات ایندیوم فسفر زینک سولفید عامل دار شده با فولات و گلومزامین کونژوگه با دوکسوروبیسین

رنجبر نوازی, زهرا and اسکندانی, مرتضی and جوهری اهر, محمد and نعمتی(Sharif University), علی and اکبری, حمید and داوران, سودابه and امیدی, یداله (1396) کوانتوم دات ایندیوم فسفر زینک سولفید عامل دار شده با فولات و گلومزامین کونژوگه با دوکسوروبیسین. Journal of Drug Targeting ــ online . pp. 1-11. شاپا 1061-186X

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Official URL: http://www.tandfonline.com/doi/abs/10.1080/1061186...


Title

Doxorubicin conjugated D-glucosamine- and folate- bi-functionalised InP/ZnS quantum dots for cancer cells imaging and therapy

English Abstract

Nanoscaled quantum dots (QDs), with unique optical properties have been used for the development of theranostics. Here, InP/ZnS QDs were synthesised and functionalised with folate (QD-FA), D-glucosamine (QD-GA) or both (QD-FA-GA). The bi-functionalised QDs were further conjugated with doxorubicin (QD-FA-GA-DOX). Optimum Indium to fatty acid (In:MA) ratio was 1:3.5. Transmission electron microscopy (TEM) micrographs revealed spherical morphology for the QDs (11 nm). Energy-dispersive spectroscopy (EDS) spectrum confirmed the chemical composition of the QDs. MTT analysis in the OVCAR-3 cells treated with bare QDs, QD-FA, QD-GA, QD-FA-GA and QD-FA-GA-DOX (0.2 mg/mL of QDs) after 24 h indicated low toxicity for the bare QDs and functionalised QDs (about 80–90% cell viability). QD-FA-GA-DOX nanoparticles elicited toxicity in the cells. Cellular uptake of the engineered QDs were investigated in both folate receptor (FR)-positive OVCAR-3 cells and FR-negative A549 cells using fluorescence microscopy and FACS flow cytometry. The FA-functionalised QDs showed significantly higher uptake in the FR-positive OVCAR-3 cells, nonetheless the GA-functionalised QDs resulted in an indiscriminate uptake in both cell lines. In conclusion, our findings indicated that DOX-conjugated FA-armed QDs can be used as theranostics for simultaneous imaging and therapy of cancer.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :زهرا رنجبر نوازی
نویسنده :مرتضی اسکندانی
نویسنده :محمد جوهری اهر
نویسنده :علی نعمتی(Sharif University)
نویسنده :حمید اکبری
نویسنده مسئول :سودابه داوران
نویسنده مسئول :یداله امیدی
Additional Information:Impact Factor (2016) 3.068 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts, BIOBASE/Current Awareness in Biological Sciences, BIOSIS, Clinical Nuclear Medicine; Current Contents/Life Sciences ;EMBASE/Excerpta Medica, International Pharmaceutical Abstracts نوع مقاله:Original Article
کلیدواژه ها (انگلیسی):InP/ZnS quantum dots, folic acid, solid tumours, theranostics, targeted drug delivery
Subjects:QV pharmacology > QV 737 Pharmaceutical Biotechnology
QV pharmacology > QV 744 Medicinal Chemistry
QV pharmacology > QV 25 Pharmaceutical Biomaterials
QV pharmacology > QV 778 Pharmaceutical Nanotechnology
QV pharmacology
Divisions:School of Pharmacy > Department of Medicinal Chemistry
ID Code:9460
Deposited By: MR Mohammad Johari-Ahar
Deposited On:19 Sep 1396 11:51
Last Modified:19 May 1398 14:47

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