تروگزروتین از نورون های هیپوکامپ در برابر استرس اکسیداتیو و آپوپتوز القاء شده با بتا آمیلوئید محافظت می کند

فرج دخت, فرشته and امانی, محمد and میرزائی باویل, فریبا and علی همتی, علیرضا and محدث, گیسو and ببری, شیرین (1396) تروگزروتین از نورون های هیپوکامپ در برابر استرس اکسیداتیو و آپوپتوز القاء شده با بتا آمیلوئید محافظت می کند. EXCLI Journal ــ 16 . pp. 1081-1089. شاپا 1611-2156

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English Abstract

Alzheimer’s disease (AD) is an age-related neurodegenerative disease linked with increased production and/or deposition of amyloid-beta (Aβ) in the brain. The aim of the present study was to investigate the possible neuro- protective effect of troxerutin on an animal model of Alzheimer's disease. Alzheimer model was induced by a single dose intracerebroventricular (ICV) injection of Aβ 1–42 (5 nmol/5 µl). Thereafter, troxerutin (300 mg/kg) was gavaged for 14 days. The hippocampal malondialdehyde (MDA) levels and enzymatic activities of superoxide dismutase OD), glutathione peroxidase (GPx), and acetylcholinesterase (AChE) were measured using enzyme- linked immunosorbent assay (ELISA) method. In addition, the number of apoptotic cells in the dentate gyrus (DG) was assessed by TUNEL kit. The results showed that ICV microinjection of Aβ 1-42 increased MDA levels, re- duced SOD and GPx, and increased AChE activities in the hippocampus. Chronic administration of troxerutin significantly attenuated MDA levels and AChE activity and increased SOD and GPx activities in the hippocampus. Moreover, the number of apoptotic cells was decreased by troxerutin treatment. Taken together, our study demon- strated that troxerutin could increase the resistance of hippocampal neurons against apoptosis, at least in part, by diminishing the activity of AChE and oxidative stress. Therefore, troxerutin may have beneficial effects in the management of Alzheimer's disease

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :فرشته فرج دخت
نویسنده :محمد امانی
نویسنده :فریبا میرزائی باویل
نویسنده :علیرضا علی همتی
نویسنده :گیسو محدث
نویسنده مسئول :شیرین ببری
Additional Information:IF: 2.112 Indexed in: ISI, Scopus, PubMed/PMC, Embase
کلیدواژه ها (انگلیسی):Alzheimer’s disease, amyloid beta, acetylcholinesterase, oxidative stress
Subjects:QT physiology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:9466
Deposited By: MS Soghra Golmaghani
Deposited On:18 Sep 1396 08:26
Last Modified:01 May 1402 09:49

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