بررسی رابطه ی اسیدوز و هایپرکاپنی با کورپولمونال در بیماران

حسینی نیا, سعید and علی عسگرزاده خیاوی, شفق and زمانی, بیژن and حبیب زاده, افشین and خیرجو, سعید and صادقیه اهری, سعید (1396) بررسی رابطه ی اسیدوز و هایپرکاپنی با کورپولمونال در بیماران. Journal of Analytical Research in Clinical Medicine ــ 5 (4). pp. 128-133. شاپا 2345-4970


Official URL: http://journals.tbzmed.ac.ir/JARCM/Abstract/JARCM_...


The relationship between acidosis and hypercapnia with Cor pulmonale in patients with chronic obstructive pulmonary disease

English Abstract

Abstract Introduction: Cor pulmonale or right ventricular (RV) enlargement is cardiovascular complication of the chronic obstructive pulmonary disease (COPD). Hypoxic pulmonary vasoconstriction, hypercapnia, acidosis and pulmonary vascular remodeling are suggested as possible mechanisms of cor pulmonale. In this study, we aimed to evaluate the correlation between acidosis and hypercapnia with corpulmonale in patients with COPD. Methods: In this cross-sectional analytical study, 100 patients (56 men and 44 women with mean age of 66.53 ± 10.63 years) with moderate to severe COPD exacerbation were included. Complete history taking and physical examination as well as atrial blood gas, pulmonary function test (PFT) and echocardiography were performed. Disease severity was defined according to global initiative for obstructive lung disease (GOLD), Modified Medical Research Council (mMRC) and COPD Assessment Test (CAT) criteria. Patients with cor pulmonale were defined and findings were compared between patients with and without cor pulmonale. Results: Forty-two patients had cor pulmonale. There was no significant difference in hypercapnia between groups. Cor pulmonale patients, compared to non-cor pulmonale, had significantly lower forced expiratory volume in the first second (FEV1) (P = 0.020), higher tricuspid regurgitation (TR) (P = 0.001) and pulmonary hypertension (P = 0.020). There was significantly negative correlation between RV thickness with FEV1/forced vital capacity (FCV) (r = -0.239, P = 0.010) and RV size with FEV1/FVC (r = -0.312, P = 0.002) and positive correlation with partial pressure of carbon dioxide (PaCO2) (r = 0.312, P = 0.002) and bicarbonate (HCO3) (r = 0.258, P = 0.009). Conclusion: Cor pulmonale in the course of COPD accompanies with adverse outcome. These patients have worse spirometry and left ventricle echocardiographic findings, but have no difference in arterial blood gas (ABG) findings

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سعید حسینی نیا
نویسنده مسئول :شفق علی عسگرزاده خیاوی
نویسنده :بیژن زمانی
نویسنده :سعید صادقیه اهری
Additional Information:Indexed in: DOAJ, J-gate and Google Scholar, Magiran برگرفته از پایان نامه
کلیدواژه ها (انگلیسی):Chronic Obstructive Pulmonary Disease, Cor Pulmonale, Echocardiography, Spirometry
Subjects:WF Respiratory System
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:9484
Deposited By: Ms Zeynab Imani
Deposited On:18 Sep 1396 11:41
Last Modified:08 Mar 1397 14:51

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