نگاهی به اهمیت شیمیایی و بیولوژیکی هسته پیرولیدینون

حسین زاده, زهرا and رمضانی, علی and حسین زاده, کمال الدین and رزاقی اصل, نیما and گران لو, فریده (1397) نگاهی به اهمیت شیمیایی و بیولوژیکی هسته پیرولیدینون. Current Organic Synthesis ــ 15 (2). pp. 166-178. شاپا 1570-1794

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An Overview on Chemistry and Biological Importance of Pyrrolidinone

English Abstract

Background: Pyrrolidinone is a five membered heterocyclic ring that is a versatile lead compound for designing powerful bioactive agents. Pyrrolidinone nucleus is one of the most important heterocyclic compound indicating notable pharmaceutical effects. Many procedures for the preparation of pyrrolidinone and also their various reactions offer great scope in the field of medicinal chemistry. This fascinating group of compounds has diverse pharmacological activities such as antibacterial, antifungal, anticancer and anticonvulsant. Objective: The review article proposes to classify comprehensive information on chemistry and pharmaceutical effects of pyrrolidinone in order to open new viewpoint for future studies. Conclusion: It is clear from the review of the topic that a wide spectrum of pyrrolidinone analogues have been synthesized and the majority of these derivatives have indicated different significant biological activities. Thus, these analogues can be used for future progression of novel drugs against many more poor agents.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :زهرا حسین زاده
نویسنده مسئول :علی رمضانی
نویسنده :کمال الدین حسین زاده
نویسنده :نیما رزاقی اصل
نویسنده :فریده گران لو
Additional Information:IF: 1.841 Indexed in: ISI, Scopus
کلیدواژه ها (انگلیسی):Pyrrolidinone, Heterocyclic, Biological activities, Antimicrobial, Anticancer, Industrial applications
Subjects:QV pharmacology > QV 744 Medicinal Chemistry
QV pharmacology
Divisions:School of Pharmacy > Department of Medicinal Chemistry
ID Code:9486
Deposited By: Mrs sepideh Dashti
Deposited On:21 Sep 1396 08:35
Last Modified:05 Dec 1400 08:22

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