اثرات محافظتی مانو ذرات کوانزیم کیو ده بر روی سمیت کبدی ایجاد شده با دیکلرووس

افتخاری, عزیز and احمدیان, الهام and اعظمی, آیدا and جوهری اهر, محمد and اقبال, محمد علی (1396) اثرات محافظتی مانو ذرات کوانزیم کیو ده بر روی سمیت کبدی ایجاد شده با دیکلرووس. Environmental Toxicology ــ online . pp. 1-11. شاپا 1522-7278


Official URL: http://onlinelibrary.wiley.com/doi/10.1002/tox.225...


Protective effects of coenzyme Q10 nanoparticles on dichlorvos-induced hepatotoxicity and mitochondrial/lysosomal injury

English Abstract

Development of biocompatible antioxidant nanoparticles for xenobiotic-induced liver disease treatment by oral or parenteral administration is of great interest in medicine. In the current study, we demonstrate the protective effects of coenzyme Q10 nanoparticles (CoQ10-NPs) on hepatotoxicity induced by dichlorvos (DDVP) as an organophosphate. Although CoQ10 is an efficient antioxidant, its poor bioavailability has limited the applications of this useful agent. First, CoQ10-NPs were prepared then characterized using dynamic light scattering (DLS) and transmission electron microscopy (TEM). In DDVP-treated and non-treated hepatocytes in the presence of CoQ10-NPs, cell viability, the level of reactive oxygen species (ROS), lipid peroxidation (LPO), mitochondrial membrane potential (MMP), lysosome membrane integrity, and cellular glutathione (GSH) content were measured. The prepared CoQ10-NPs were mono-dispersed and had narrow size distribution with average diameter of 54 nm. In the in vivo study, we evaluated the enzymes, which are involved in the antioxidant system for maintenance of normal liver function. In comparison to nonparticulate CoQ10, the CoQ10-NPs efficiently decreased the ROS formation, lipid peroxidation and cell death. Also, particulate form of CoQ10 improved MMP, GSH level and lysosome membrane integrity. In the in vivo, study, we revealed that CoQ10-NPs were better hepatoprotective than its nonparticulate form (P < .05). Altogether, we propose that the CoQ10-NPs have potential capability to be used as a therapeutic and prophylactic agent for poisoning that is induced by organophosphate agents, especially in the case of DDVP. Furthermore, these positive remarks make this nanoparticle amenable for the treatment of xenobiotic-induced liver diseases.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :عزیز افتخاری
نویسنده :الهام احمدیان
نویسنده :آیدا اعظمی
نویسنده :محمد جوهری اهر
نویسنده مسئول :محمد علی اقبال
Additional Information:Impact Factor (2016) 2.937 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts Service , Abstracts on Hygiene & Communicable Diseases (CABI) , Agricultural & Environmental Science Database ,(ProQuest), Biological Science Database, نوع مقاله: RESEARCH ARTICLE
کلیدواژه ها (انگلیسی):Nanoparticles, Dichlorvos, coenzyme Q10, Organophosphates, oxidative stress, cytotoxicity
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology > QV 744 Medicinal Chemistry
QV pharmacology > QV 25 Pharmaceutical Biomaterials
QV pharmacology > QV 778 Pharmaceutical Nanotechnology
QV pharmacology
Divisions:School of Pharmacy > Department of Medicinal Chemistry
ID Code:9488
Deposited By: Dr Mohammad Johari-Ahar
Deposited On:21 Sep 1396 09:17
Last Modified:21 Sep 1396 09:17

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