نگاهی جدید به ایمونوپاتوژنز هپاتیت بی

پیری دوگاهه, هادی and مشکات, زهرا and حبیب زاده, شهرام and ارزنلو, محسن and محمدشاهی, جعفر and رستمی, سینا and گرایلی, سینا and تیمورپور, رقیه (1396) نگاهی جدید به ایمونوپاتوژنز هپاتیت بی. virus research ــ 245 . pp. 29-43. شاپا 0168-1702

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Official URL: http://www.sciencedirect.com/science/article/pii/S...


Current concepts on immunopathogenesis of hepatitis B virus infection.

English Abstract

Hepatitis B virus (HBV) infection is a leading cause of liver damage and hepatic inflammation. Upon infection, effective antiviral responses by CD8+ T cells, CD4+ T cells, Natural killer (NK) cells, and monocytes can lead to partial or complete eradication of the viral infection. To date, many studies have shown that the production of inhibitory cytokines such as Interleukin 10 (IL-10), Transforming growth factor beta (TGF-β), along with dysfunction of the dendritic cells (DCs), and the absence of efficient innate immune responses could lead to T cell exhaustion, development of persistent infection, and inability to eradicate the viral infection from liver. Understanding the immunopathogenesis of the virus could be useful in providing further insights toward novel strategies in the eradication of HBV infection.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :هادی پیری دوگاهه
نویسنده :زهرا مشکات
نویسنده :شهرام حبیب زاده
نویسنده :محسن ارزنلو
نویسنده :جعفر محمدشاهی
نویسنده :سینا رستمی
نویسنده :سینا گرایلی
نویسنده مسئول :رقیه تیمورپور
Additional Information:IF: 2.736 Indexed in: ISI, PubMed/Medline, Scopus, EMBASE
کلیدواژه ها (انگلیسی):Dendritic cells; Monocytes; Virus
Subjects:QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
Faculty of Medicine > Department of Basic Sciences > Department of Microbiology
ID Code:9576
Deposited By: Dr Roghayeh Teimourpour
Deposited On:19 Oct 1396 08:38
Last Modified:23 Dec 1401 09:55

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