خادمی, فرزاد ، درخشان, محمد ، یوسفی اوروند, ارشید ، تفقدی, محسن ، سلیمان پور, سامان (1396) واکسن های زیرواحدی چندمرحله ای مایکوباکتریوم توبرکلوزیس: جایگزین واکسن BCG یا تقویت کننده BCG اولیه؟. Expert Review of Vaccines ــ 17 (1). ص.ص.31-44. شاپا 1476-0584
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آدرس اینترنتی رسمی : http://www.tandfonline.com/doi/full/10.1080/147605...
عنوان انگليسی
Multi-stage subunit vaccines against Mycobacterium tuberculosis: an alternative to the BCG vaccine or a BCG-prime boost
خلاصه انگلیسی
Introduction: More than two billion people are latently infected with Mycobacterium tuberculosis. Most tuberculosis (TB)-subunit vaccines currently in various stages of clinical trials are designed for prevention of active TB, but not to prevent reactivation of latent TB-infection. Thus, there is an urgent need for an effective multi-stage vaccine based on early-expressed and latently-expressed antigens that prevents both acute and latent infections. Areas covered: Here, we reviewed the published pre-clinical and clinical studies of multi-stage subunit vaccines against TB, and the protective capacities of the vaccines were compared with BCG, either alone or in combination with different vaccine delivery systems/adjuvants. The results revealed that multi-stage subunit vaccines induced a wide variety of immune-responses to all forms of TB, including CD8 + T-cell-mediated cytolytic and IFN-γ responses comparable to those induced by the BCG. They could potentially be used as a booster vaccine to improve the efficacy of the BCG. Expert commentary: Multi-stage TB-vaccines could boost BCG-primed immunity, decrease bacterial loads and provide efficient protection against progressive TB-infection, especially in the latent phase. These types of vaccines administered before and after TB-infection can act as pre-exposure, post-exposure and even therapeutic vaccines. In the near future, these vaccines could provide a new generation of prime-vaccines or BCG prime-boosters.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | فرزاد خادمی |
نویسنده : | محمد درخشان |
نویسنده : | ارشید یوسفی اوروند |
نویسنده : | محسن تفقدی |
نویسنده مسئول : | سامان سلیمان پور |
ضریب تاثیر و نمایه مجلات: | Impact factor (2016) 3.555 Indexed in: ISI, PubMed/Medline/Index Medicus, Scopus |
کلیدواژه ها (انگلیسی): | Mycobacterium tuberculosis, Multistage vaccines, BCG, Delivery systems/adjuvants |
موضوعات : | QW میکروب شناسی و ایمنی شناسی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش میکروبیولوژی |
کد شناسایی : | 9605 |
ارائه شده توسط : | دکتر فرزاد خادمی |
ارائه شده در تاریخ : | 09 بهمن 1396 09:37 |
آخرین تغییر : | 26 دی 1401 10:37 |
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