واکسن های زیرواحدی چندمرحله ای مایکوباکتریوم توبرکلوزیس: جایگزین واکسن BCG یا تقویت کننده BCG اولیه؟

خادمی, فرزاد and درخشان, محمد and یوسفی اوروند, ارشید and تفقدی, محسن and سلیمان پور, سامان (1396) واکسن های زیرواحدی چندمرحله ای مایکوباکتریوم توبرکلوزیس: جایگزین واکسن BCG یا تقویت کننده BCG اولیه؟. Expert Review of Vaccines ــ 17 (1). pp. 31-44. شاپا 1476-0584

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Official URL: http://www.tandfonline.com/doi/full/10.1080/147605...


Multi-stage subunit vaccines against Mycobacterium tuberculosis: an alternative to the BCG vaccine or a BCG-prime boost

English Abstract

Introduction: More than two billion people are latently infected with Mycobacterium tuberculosis. Most tuberculosis (TB)-subunit vaccines currently in various stages of clinical trials are designed for prevention of active TB, but not to prevent reactivation of latent TB-infection. Thus, there is an urgent need for an effective multi-stage vaccine based on early-expressed and latently-expressed antigens that prevents both acute and latent infections. Areas covered: Here, we reviewed the published pre-clinical and clinical studies of multi-stage subunit vaccines against TB, and the protective capacities of the vaccines were compared with BCG, either alone or in combination with different vaccine delivery systems/adjuvants. The results revealed that multi-stage subunit vaccines induced a wide variety of immune-responses to all forms of TB, including CD8 + T-cell-mediated cytolytic and IFN-γ responses comparable to those induced by the BCG. They could potentially be used as a booster vaccine to improve the efficacy of the BCG. Expert commentary: Multi-stage TB-vaccines could boost BCG-primed immunity, decrease bacterial loads and provide efficient protection against progressive TB-infection, especially in the latent phase. These types of vaccines administered before and after TB-infection can act as pre-exposure, post-exposure and even therapeutic vaccines. In the near future, these vaccines could provide a new generation of prime-vaccines or BCG prime-boosters.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :فرزاد خادمی
نویسنده :محمد درخشان
نویسنده :ارشید یوسفی اوروند
نویسنده :محسن تفقدی
نویسنده مسئول :سامان سلیمان پور
Additional Information:Impact factor (2016) 3.555 Indexed in: ISI, PubMed/Medline/Index Medicus, Scopus
کلیدواژه ها (انگلیسی):Mycobacterium tuberculosis, Multistage vaccines, BCG, Delivery systems/adjuvants
Subjects:QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Microbiology
ID Code:9605
Deposited By: Dr Farzad Khademi
Deposited On:09 Nov 1396 09:37
Last Modified:26 Oct 1401 10:37

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