خادمی, فرزاد and درخشان, محمد and یوسفی اوروند, ارشید and تفقدی, محسن and سلیمان پور, سامان (1396) واکسن های زیرواحدی چندمرحله ای مایکوباکتریوم توبرکلوزیس: جایگزین واکسن BCG یا تقویت کننده BCG اولیه؟. Expert Review of Vaccines ــ 17 (1). pp. 31-44. شاپا 1476-0584
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Official URL: http://www.tandfonline.com/doi/full/10.1080/147605...
Title
Multi-stage subunit vaccines against Mycobacterium tuberculosis: an alternative to the BCG vaccine or a BCG-prime boost
English Abstract
Introduction: More than two billion people are latently infected with Mycobacterium tuberculosis. Most tuberculosis (TB)-subunit vaccines currently in various stages of clinical trials are designed for prevention of active TB, but not to prevent reactivation of latent TB-infection. Thus, there is an urgent need for an effective multi-stage vaccine based on early-expressed and latently-expressed antigens that prevents both acute and latent infections. Areas covered: Here, we reviewed the published pre-clinical and clinical studies of multi-stage subunit vaccines against TB, and the protective capacities of the vaccines were compared with BCG, either alone or in combination with different vaccine delivery systems/adjuvants. The results revealed that multi-stage subunit vaccines induced a wide variety of immune-responses to all forms of TB, including CD8 + T-cell-mediated cytolytic and IFN-γ responses comparable to those induced by the BCG. They could potentially be used as a booster vaccine to improve the efficacy of the BCG. Expert commentary: Multi-stage TB-vaccines could boost BCG-primed immunity, decrease bacterial loads and provide efficient protection against progressive TB-infection, especially in the latent phase. These types of vaccines administered before and after TB-infection can act as pre-exposure, post-exposure and even therapeutic vaccines. In the near future, these vaccines could provide a new generation of prime-vaccines or BCG prime-boosters.
Item Type: | Article |
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زبان سند : | انگلیسی |
نویسنده اول : | فرزاد خادمی |
نویسنده : | محمد درخشان |
نویسنده : | ارشید یوسفی اوروند |
نویسنده : | محسن تفقدی |
نویسنده مسئول : | سامان سلیمان پور |
Additional Information: | Impact factor (2016) 3.555 Indexed in: ISI, PubMed/Medline/Index Medicus, Scopus |
کلیدواژه ها (انگلیسی): | Mycobacterium tuberculosis, Multistage vaccines, BCG, Delivery systems/adjuvants |
Subjects: | QW Microbiology and Immunology |
Divisions: | Faculty of Medicine > Department of Basic Sciences > Department of Microbiology |
ID Code: | 9605 |
Deposited By: | Dr Farzad Khademi |
Deposited On: | 09 Nov 1396 09:37 |
Last Modified: | 26 Oct 1401 10:37 |
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