PCSK9 و عفونت: یک ارتباط بالقوه مفید یا خطرناک؟

خادمی, فرزاد and ممتازی بروجنی, امیر عباس and Reiner, Željko and Banach, Maciej and Al-Rasadi, Khalid and صاحبکار, امیر حسین (1397) PCSK9 و عفونت: یک ارتباط بالقوه مفید یا خطرناک؟. Journal of Cellular Physiology ــ 233 (4). pp. 2920-2927. شاپا 0021-9541

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/jc...


PCSK9 and infection: A potentially useful or dangerous association

English Abstract

Elevated plasma low‐density lipoprotein‐cholesterol (LDL‐C) concentration is the most important risk factor for atherosclerotic cardiovascular diseases (CVDs). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a ubiquitously expressed serine proteinase which plays a key role in cholesterol metabolism, but has been found to be implicated in some other lipid‐independent physiological processes. In this review, the role of PCSK9 was evaluated not only concerning lipid metabolism but also hepatitis C virus (HCV) infection, bacterial infections/sepsis, and septic shock. Collected data from clinical trials revealed that treatment with PCSK9 inhibitors has beneficial effects in lowering LDL‐C via inhibition of LDL‐receptors (LDL‐R), an antiviral effect on HCV infection via down‐regulating the surface expression of LDL‐R and CD81 on hepatic cells, and a positive association with increased inflammatory responses, as well as with septic shock by down‐regulation of hepatocyte LDL‐R. On the other hand, PCSK9 inhibition by therapeutic fully humanized antibodies has positive effects in reducing elevated LDL‐C. However, their safety and tolerability is an important issue which has to be taken into consideration.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :فرزاد خادمی
نویسنده مسئول :امیر حسین صاحبکار
Additional Information:Impact Factor (2016) 4.08 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts Service, Abstracts on Hygiene & Communicable Diseases (CABI), Agricultural & Environmental Science Database, BIOBASE: Current Awareness in Biological Sciences, Biochemistry & Biophysics Citation Index, Embase
کلیدواژه ها (انگلیسی):cholesterol, hepatitis C virus, infection, LDL receptor, PCSK9
Subjects:QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Microbiology
ID Code:9634
Deposited By: دکتر فرزاد خادمی
Deposited On:17 Mar 1397 11:06
Last Modified:17 Mar 1397 11:06

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