title

ویژگی سویه های هلیکوباکتر پیلوری مقاوم به کلاریترومایسین در ایران: مطالعه مروری و متاآنالیز

خادمی, فرزاد and صاحبکار, امیر حسین and واعظ, حمید and ارزنلو, محسن and پیری دوگاهه, هادی (1396) ویژگی سویه های هلیکوباکتر پیلوری مقاوم به کلاریترومایسین در ایران: مطالعه مروری و متاآنالیز. Journal of Global Antimicrobial Resistance ــ 10 . pp. 171-178. شاپا 2213-7165

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Title

Characterization of clarithromycin-resistant Helicobacter pylori strains in Iran: A systematic review and meta-analysis

English Abstract

Background The high prevalence of clarithromycin-resistant strains of Helicobacter pylori is a main challenge for the successful treatment of gastrointestinal infections. Point mutations in the 23S rRNA gene are one of the main mechanisms leading to the resistance to clarithromycin in Iran. The purpose of the present review was to evaluate the prevalence of clarithromycin-resistant H. pylori strains in Iran and to identify the major molecular mechanisms of resistance in the resistant isolates. Methods Using related keywords and computer search in English and Persian databases (up to November 21, 2016), available data about prevalence of clarithromycin-resistant H. pylori strains and molecular mechanisms of resistance in Iran were retrieved. Relevant articles were selected using pre-defined inclusion and exclusion criteria. Results The results of the meta-analysis showed that the overall prevalence of clarithromycin-resistant H. pylori strains in Iran is 14.7%. The highest and the lowest resistance to clarithromycin were reported from Kashan (33.7%) and Rasht (5.5%), respectively. The most prevalent point mutations in Iran were A2143G (59.1%), A2142G (17.8%), A2142C (8.8%), and A2144G (6.2%), respectively. Conclusion The prevalence of clarithromycin-resistant H. pylori strains was in an acceptable level in our region. Therefore, clarithromycin can be used for the eradication of H. pylori infection in Iran. However, it seems that investigation about the role of other mechanisms involved in the induction of resistance to clarithromycin is needed.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :فرزاد خادمی
نویسنده :محسن ارزنلو
نویسنده :هادی پیری دوگاهه
Additional Information:Impact Factor (2016) 1.276 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, ScienceDirect
کلیدواژه ها (انگلیسی):Helicobacter pylori; Clarithromycin resistance; Point mutation; Iran
Subjects:QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Microbiology
ID Code:9635
Deposited By: دکتر فرزاد خادمی
Deposited On:08 Mar 1397 15:14
Last Modified:08 Mar 1397 15:14

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