ترکیبات کایرال بی فنیل های پلی کلره 95 و 149 در هوای داخل، گیاهان و نمونه های غذا و مدفوع

هاراد, استوارت and رن, جیان زیانگ and حضرتی, صادق and رابسون, متیو (1385) ترکیبات کایرال بی فنیل های پلی کلره 95 و 149 در هوای داخل، گیاهان و نمونه های غذا و مدفوع. Chemosphere ــ 63 (8). pp. 1368-1376. شاپا 0045-6535

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Chiral signatures of PCB#s 95 and 149 in indoor air, grass, duplicate diets and human faeces

English Abstract

Chiral signatures of PCB#s 95 and 149 are reported for indoor air, grass, omnivorous and vegan duplicate human diet homogenates, and human faeces. Comparison of chiral signatures of both congeners in grass with those reported previously for outdoor air (measured at a height of 1.5 m) and soil at the same location suggest that volatilisation of PCBs present in soil may exert a significant influence on concentrations in grass. Duplicate diet homogenates display racemic signatures for both congeners. Alongside the racemic signatures in both outdoor and indoor air, this implies that human intake via diet and inhalation is racemic, and that the previously observed variation between individuals in the extent of enantioselective degradation in human liver samples indicates possible inter-individual variation in ability to metabolise PCBs. Chiral signatures of PCB# 95 in the 10 human faecal samples analysed indicate 8 to be racemic, but 2 to display an excess of the 2nd eluting enantiomer. This is consistent with the excess of the 1st eluting enantiomer reported elsewhere for human liver samples, as it implies enantioselective excretion of the 2nd eluting enantiomer. However, the racemic residues for PCB# 95 in the majority of faecal samples are a possible indication that enantioselective interaction of chiral PCBs with cytochrome P450 occurs slowly. The racemic or near-racemic signatures observed for PCB# 95 and 149 in indoor air match closely those in outdoor air, but differ from those in soil, adding to the weight of evidence that ventilation of indoor air is a far more significant contributor to outdoor air concentrations than volatilisation of PCBs from soil.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :استوارت هاراد
Additional Information:Impact factor: 3.054 Abstracting and Indexing :1- MEDLINE , Science Citation Index (ISI) 2- Scopus , EMBASE , BIOSIS, Chemical Abstracts 3- Analytical Abstracts, Aqualine Abstracts, Aqualine Abstracts , Cambridge Scientific Abstracts, Current Contents/Agriculture, Biology & Environmental Sciences, Elsevier BIOBASE, Environmental Periodicals Bibliography, PASCAL/CNRS, Research Alert SCISEARCH
کلیدواژه ها (انگلیسی):Enantioselective analysis ; PCBs
Subjects:WA Public Health > WA 400 Occupational Medicin, health and hygiene
WA Public Health > WA 400 Occupational Medicin, health and hygiene
Divisions:Faculty of Health > Department of Environmental health
ID Code:967
Deposited By: Dr Sadeg Hazrati
Deposited On:02 Dec 1388
Last Modified:23 Nov 1391 09:19

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