ارزیابی سرم فاکتور رشد جنینی در پیشگیری از نتایج بارداری در زنان با پره اکلامپسی

کهنمویی, فریبا and پورفرضی, فرهاد and احسانی, سمانه (1396) ارزیابی سرم فاکتور رشد جنینی در پیشگیری از نتایج بارداری در زنان با پره اکلامپسی. International Journal of Advances in Medicine ــ 5 (1). pp. 11-15. شاپا 3925-2349


Official URL: http://www.ijmedicine.com/index.php/ijam/article/v...


Evaluation of serum placental growth factor in predicting pregnancy outcomes in women with suspected pre-eclampsia

English Abstract

Background:Amount of Placental Growth Factor (PLGF) in the blood at 9 to 11 weeks before the onset of clinical signs of pre-eclampsia is reduced. So, diagnostic tests based on the pathophysiology of disease such as PLGF as an ideal marker for early screening in the diagnosis and management of women with preeclampsia, may be useful. The aim of this study was to investigate PLGF in predicting pregnancy outcome in women with suspected pre-eclampsia. Methods: A case - control study was conducted on 30 women with suspected pre-eclampsia and 101 healthy pregnant women which selected randomly among all pregnant women referred to clinic. Both groups were followed until pregnancy termination and in terms of pregnancy outcomes (Gestational age, Type of delivery and birth weight). Two groups were matched in terms of age, weight, education, substance abuse and socio-economic status. Placental growth factor assay was done by ELISA kit. Data collected by a checklist and analyzed by statistical methods in SPSS.19. Results:The mean PLGF level was lower for women who experienced preeclampsia compared with healthy women (71.5 pg/ml vs 272.1 pg/ml, p=0.001). Also, PLGF concentrations was very low in women with preeclampsia who had a preterm birth prematurity. Conclusions:Study findings identified PlGF as an ideal, simple and non-invasive marker for primary screening at prenatal care for women at risk of pre-eclampsia.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :فریبا کهنمویی
نویسنده :فرهاد پورفرضی
نویسنده مسئول :سمانه احسانی
Additional Information:Indexed in: Index Copernicus
کلیدواژه ها (انگلیسی):Placental growth factor, Preeclampsia, Pregnancy outcome
Subjects:WP Gynecology
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
Faculty of Medicine > Department of Anesthesiology , Obstetrics & Gynecology
ID Code:9681
Deposited By: Dr Firouz Amani
Deposited On:01 Nov 1396 10:51
Last Modified:22 Feb 1399 13:45

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